Cryptochrome: Difference between revisions

Revision as of 09:40, 20 May 2019

Function

Cryptochrome (Cry) is a flavoprotein associated with the biological clock function. In Drosophila melanogaster it is also involved in blue-light photoreception^[1].

Disease

The absence of Cry resulting in the lack of functional clock system leads to elevated proinflammatory cytokine activation and thus to increase incidence of chronic diseases such as diabetes, obesity and also cancer^[2].

3D Structures of cryptochrome

Cryptochrome 3D structures

ReferencesReferences

↑ Yoshii T, Todo T, Wulbeck C, Stanewsky R, Helfrich-Forster C. Cryptochrome is present in the compound eyes and a subset of Drosophila's clock neurons. J Comp Neurol. 2008 Jun 20;508(6):952-66. doi: 10.1002/cne.21702. PMID:18399544 doi:http://dx.doi.org/10.1002/cne.21702
↑ Narasimamurthy R, Hatori M, Nayak SK, Liu F, Panda S, Verma IM. Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12662-7. doi:, 10.1073/pnas.1209965109. Epub 2012 Jul 9. PMID:22778400 doi:http://dx.doi.org/10.1073/pnas.1209965109

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[1] Yoshii T, Todo T, Wulbeck C, Stanewsky R, Helfrich-Forster C. Cryptochrome is present in the compound eyes and a subset of Drosophila's clock neurons. J Comp Neurol. 2008 Jun 20;508(6):952-66. doi: 10.1002/cne.21702. PMID:18399544 doi:http://dx.doi.org/10.1002/cne.21702

[2] Narasimamurthy R, Hatori M, Nayak SK, Liu F, Panda S, Verma IM. Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12662-7. doi:, 10.1073/pnas.1209965109. Epub 2012 Jul 9. PMID:22778400 doi:http://dx.doi.org/10.1073/pnas.1209965109

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 </StructureSection>
-== 3D Structures of cryptochrome ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[4i6e]], [[4k0r]], [[5t5x]] – mCry-1 – mouse  <br />
-[[4jzy]], [[4gu5]], [[4k03]] – Cry-1 + FAD – ''Drosophila melanogaster''  <br />
-[[1u3c]] – AtCry-1 PHR domain + FAD - ''Arabidopsis thaliana''<br />
-[[1u3d]] – AtCry-1 PHR domain + FAD + AMPPNP<br />
-[[4ct0]] – mCry-1 + PER2  <br />
-[[4i6g]] – mCry-2 + FAD  <br />
-[[4i6j]] – mCry-2 + F-box/LRR repeat protein + S-phase kinase-associated protein  <br />
-[[4u8h]] – mCry-2 + PER2  <br />
-[[4mlp]] – mCry-2 + carbazol derivative  <br />
-[[3zxs]] – Cry-2 + FAD – ''Rhodobacter sphaeroides'' <br />
-[[2j4d]], [[2ijg]] – AtCry-3 + FAD <br />
-[[2vtb]] – AtCry-3 + FAD + DNA<br />
-[[3fy4]] – AtCry 6-4 + FAD <br />
-[[1np7]] – Cry - ''Synechocystis''  <br />
-[[6fn3]], [[5zm0]] – CrCry + FAD – ''Chlamydomonas reinhardtii''<br />
-[[6fn2]] – CrCry + FAD + alloxazine derivative <br />
-[[6fn0]] – CrCry + FAD + DNA + pyrimidine derivative <br />
 == References ==