2ix5: Difference between revisions

Revision as of 19:14, 5 November 2007

SHORT CHAIN SPECIFIC ACYL-COA OXIDASE FROM ARABIDOPSIS THALIANA, ACX4 IN COMPLEX WITH ACETOACETYL-COA

OverviewOverview

Plants produce a unique peroxisomal short chain-specific acyl-CoA oxidase, (ACX4) for beta-oxidation of lipids. The short chain-specific oxidase has, little resemblance to other peroxisomal acyl-CoA oxidases but has an, approximately 30% sequence identity to mitochondrial acyl-CoA, dehydrogenases. Two biochemical features have been linked to structural, properties by comparing the structures of short chain-specific Arabidopsis, thaliana ACX4 with and without a substrate analogue bound in the active, site to known acyl-CoA oxidases and dehydrogenase structures: (i) a, solvent-accessible acyl binding pocket is not required for oxygen, reactivity, and (ii) the oligomeric state plays a role in substrate pocket, architecture but is not linked to oxygen reactivity. The structures, indicate that the acyl-CoA oxidases may encapsulate the electrons for, transfer to molecular oxygen by blocking the dehydrogenase substrate, interaction site with structural extensions. A small binding pocket, observed adjoining the flavin adenine dinucleotide N5 and C4a atoms could, increase the number of productive encounters between flavin adenine, dinucleotide and O2.

About this StructureAbout this Structure

2IX5 is a Single protein structure of sequence from Arabidopsis thaliana with CAA and FAD as ligands. Active as Acyl-CoA oxidase, with EC number 1.3.3.6 Structure known Active Site: AC1. Full crystallographic information is available from OCA.

ReferenceReference

Controlling electron transfer in Acyl-CoA oxidases and dehydrogenases: a structural view., Mackenzie J, Pedersen L, Arent S, Henriksen A, J Biol Chem. 2006 Oct 13;281(41):31012-20. Epub 2006 Aug 3. PMID:16887802

Page seeded by OCA on Mon Nov 5 18:19:21 2007

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

Revision as of 15:16, 5 November 2007 view source OCA (talk \| contribs) Bots, Bureaucrats, Administrators 3,175,590 edits No edit summary ← Older edit		Revision as of 19:14, 5 November 2007 view source OCA (talk \| contribs) Bots, Bureaucrats, Administrators 3,175,590 edits No edit summary Newer edit →
Line 34:		Line 34:
	[[Category: peroxisome]]		[[Category: peroxisome]]

	''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 14:21:21 2007''		''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 18:19:21 2007''