Ras Protein and Pancreas Cancer: Difference between revisions
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== Disease == | == Disease == | ||
The absence of, or mutations of these proteins cause major diseases, cancers in lungs, bladder, pancreas, and heart are the most common but not the only ones. These proteins are very important for everything because they control a lot of functions in cells. The absence of, or mutations of these signaling proteins can cause terrible damage to our body. The gene KRas which produces the KRas protein, this protein participates in cellular signaling, it controls the growth and death of cells. The normal form of this protein is natural KRas but when it gets mutated, different types of cancer can be found such as lung, colorectal and pancreas. Having these changes (mutations) might have a possible stimulation in the cells’ growth causing this the spreading of the cells in the body. Is key to verify if the tumor has the shape of a mutated or natural KRas gene so that the treatment of the cancer can be planified. | The absence of, or mutations of these proteins cause major diseases, cancers in lungs, bladder, pancreas, and heart are the most common but not the only ones. These proteins are very important for everything because they control a lot of functions in cells. The absence of, or mutations of these signaling proteins can cause terrible damage to our body. The gene KRas which produces the KRas protein, this protein participates in cellular signaling, it controls the growth and death of cells. The normal form of this protein is natural KRas but when it gets mutated, different types of cancer can be found such as lung, colorectal and pancreas. Having these changes (mutations) might have a possible stimulation in the cells’ growth causing this the spreading of the cells in the body. Is key to verify if the tumor has the shape of a mutated or natural KRas gene so that the treatment of the cancer can be planified. | ||
The RAS family of small GTPases includes three genes: HRAS, NRAS, and KRAS. Each RAS protein is comprised of two major domains, the G domain and the membrane targeting domain | The RAS family of small GTPases includes three genes: HRAS, NRAS, and KRAS. Each RAS protein is comprised of two major domains, the G domain and the membrane targeting domain <ref name='Daniel'>PMID: 27096871</ref>. All of the isoforms are similar in the amino acid sequence of the G domain with major differences being restricted to the hypervariable region of their C-terminal domains. Mutations in RAS occur in residues 12, 13 and 61, and inhibit GTP hydrolysis activity (Daniel ZeitouniOrcID, 2016). The three RAS genes constitute the most frequently mutated oncogene family in human cancers; however, the specific isoform and amino acid mutation | ||
varies among cancers (Daniel ZeitouniOrcID, 2016). Mutations in HRAS are most | varies among cancers (Daniel ZeitouniOrcID, 2016). Mutations in HRAS are most | ||
frequently found in melanoma, bladder and mammary carcinoma; NRAS mutations are found in melanoma and thyroid carcinoma; and KRAS mutations are most prevalent in | frequently found in melanoma, bladder and mammary carcinoma; NRAS mutations are found in melanoma and thyroid carcinoma; and KRAS mutations are most prevalent in | ||