Cystathionine β-synthase: Difference between revisions
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==3D Structure of Human Cystathionine β-synthase (4coo)== | ==3D Structure of Human Cystathionine β-synthase (4coo)== | ||
<StructureSection load='4coo' size='340' side='right' caption='Human Cystathionine β-synthase' scene=''> | <StructureSection load='4coo' size='340' side='right' caption='Human Cystathionine β-synthase' scene=''> | ||
Cystathionine β-synthase (CBS; EC 4.2.1.22) is a unique pyridoxal 5’-phosphate (PLP) enzyme which plays a crucial role in the transsulfuration metabolic pathway of sulfur-containing amino acid, L- | Cystathionine β-synthase (CBS; EC 4.2.1.22) is a unique pyridoxal 5’-phosphate (PLP) enzyme which plays a crucial role in the transsulfuration metabolic pathway of sulfur-containing amino acid, L-homocysteine. | ||
PLP enzymes are divided into four families on the basis of similarities in three dimensional structure, sequence, secondary structure, and hydrophobicity profiles. CBS is a member of the β family or Fold type II, which also contains O-acetylserine sulfhydrylase (OASS) and O-acetyl-L-serine(thiol)lyase (OASTL)<ref>PMID:11483494</ref>. | PLP enzymes are divided into four families on the basis of similarities in three dimensional structure, sequence, secondary structure, and hydrophobicity profiles. CBS is a member of the β family or Fold type II, which also contains O-acetylserine sulfhydrylase (OASS) and O-acetyl-L-serine(thiol)lyase (OASTL)<ref>PMID:11483494</ref>. | ||