Catabolite control protein: Difference between revisions
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== Function == | == Function == | ||
'''Catabolite control protein''' (CcpA) is a regulator of carbon metabolism in gram-positive bacteria. When high concentrations of glucose-6 phosphate or fructose-1,6-diphosphate are present in the cell, they phosphorylate proteins HPr or Crh which interact with CcpA. The latter binds to DNA operator to modulate transcription.<ref>PMID:16321938</ref> | '''Catabolite control protein''' (CcpA) or '''glucose-resistant amylase regulator''' is a regulator of carbon metabolism in gram-positive bacteria. When high concentrations of glucose-6 phosphate or fructose-1,6-diphosphate are present in the cell, they phosphorylate proteins HPr or Crh which interact with CcpA. The latter binds to DNA operator to modulate transcription.<ref>PMID:16321938</ref> | ||
== Structural highlights == | == Structural highlights == | ||
CcpA phosphorylation activity is carried out by a <scene name='57/570565/Cv/2'>phosphorylated Ser residue</scene> (PDB entry [[2fep]]).<ref>PMID:8195089</ref> <ref>PMID:8596444</ref> | CcpA phosphorylation activity is carried out by a <scene name='57/570565/Cv/2'>phosphorylated Ser residue</scene> (PDB entry [[2fep]]).<ref>PMID:8195089</ref> <ref>PMID:8596444</ref> | ||
==3D structures of catabolite control protein== | |||
[[Catabolite control protein 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
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**[[2oen]] - BmCcpA + phosphocarrier protein HPr <br /> | **[[2oen]] - BmCcpA + phosphocarrier protein HPr <br /> | ||
**[[2fep]] - BsCcpA + phosphocarrier protein HPr – ''Bacillus subtilis''<br /> | **[[2fep]] - BsCcpA + phosphocarrier protein HPr – ''Bacillus subtilis''<br /> | ||
**[[4rk6]] - WpCcpA + glucose – ''Weissella paramesenteroides'' <br /> | |||
**[[4rk7]] - WpCcpA + sucrose <br /> | |||
*CcpA ternary complex | *CcpA ternary complex | ||
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**[[1zvv]] – BsCcpA + catabolite repression Crh + DNA <br /> | **[[1zvv]] – BsCcpA + catabolite repression Crh + DNA <br /> | ||
**[[3oqm]], [[3oqn]], [[3oqo]] - BsCcpA + phosphocarrier protein HPr + DNA<br /> | **[[3oqm]], [[3oqn]], [[3oqo]] - BsCcpA + phosphocarrier protein HPr + DNA<br /> | ||
*CcpC | |||
**[[5z72]] - CcpC + citrate – ''Bacillus velezensis''<br /> | |||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||