Caspase

Caspase (CASP) are cysteine-aspartic proteases (see Protease) which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP. CASP-1 (or Interleukin-1 beta converting enzyme, ICE) cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein. See Human Caspase-1 CASP-3 or (Apopain; Cysteine protease CPP32) interacts with CASP-8 and CASP-9 during cell apoptosis. See Sandox Bay Serrano, Student Projects for UMass Chemistry 423 Spring 2012-5 and Caspase-3 Regulatory Mechanisms CASP-6 is involved in the activation of cascade of caspases during apoptosis. See Molecular Playground/Caspase-6 (new) and Caspase-6 and neurodegeneration CASP-7 is a heterodimer consisting of P20 (human residues 1-198) and P11 (human residues 199-303) subunits. CASP-7 catalytic domain consists of residues 57-303. is an important initiator CASP and drICE is an effector of apoptosis CASP in Drosophila melanogaster. See Molecular Playground/Caspase-7 Dynamics and Molecular Playground/Executioner Caspase-7 CASP-9 is an aspartic protease linked to mitochondrial death pathway. See Molecular Playground/Caspase-9 Regulation. Metacaspase (MCASP) are arginine/lysine specific CASP. MCASP are found in plants and fungi. 3D structures of caspase Caspase 3D structures

spinqualitylabelsall models CASP-2 subunit P18 (purple, yellow) and subunit P12 (green, cyan) complex with polypeptide inhibitor (salmon, blue), aspartic aldehyde and acetyl group, 1pyo Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of caspase3D structures of caspase

Updated on 28-April-2019

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• CASP-1
  • 3e4c – hpro-CASP (mutant) - human
    
  • 2nn3 – pro-SfCASP (mutant) – Spodoptera frugiperda
    
  • 5fna – hCASP CARD domain – Cryo-EM
    
  • 1sc1, 1sc4 - hCASP (mutant)
    
  • 1sc3 - hCASP (mutant) + malonate
    
  • 6bz9 - hCASP + polypeptide inhibitor
    
  • 3d6f, 3d6h, 3d6m, 1ibc, 5mtk, 5mmv, 6f6r - hCASP (mutant) + polypeptide inhibitor
    
  • 2hbq, 1bmq, 3ns7 - hCASP + inhibitor
    
  • 2h4w, 2h4y, 2h51, 2h54, 2hbr, 2hby, 2hbz, 2h48, 2fqq, 1rwk, 1rwm, 1rwn, 1rwo, 1rwp, 1rwv, 1rww, 1rwx - hCASP (mutant) + inhibitor
    
  • 1ice – hCASP + tetrapeptide aldehyde
    
  • 1m72 – SfCASP + polypeptide inhibitor
    
• CASP-2
  • 2p2c – hCASP
    
  • 3r7s - hCASP subunits P12, P18
    
  • 1pyo, 3r5j, 3r6g, 3r6l, 3r7b, 3r7n, 3rjm - hCASP + polypeptide inhibitor
    
• CASP-3
  • 1qx3 - hCASP
    
  • 2xyg, 2xyh, 2xyp, 4jje – hCASP subunits P12, P17 + inhibitor
    
  • 2xzd, 2xzt, 2y0b - hCASP subunits P12, P17 + DARPIN-3.4
    
  • 3pcx, 3pd1, 3pd0, 3gjq, 3gjr, 3gjs, 3gjt, 3edq, 3edr, 2cnk, 2cnl, 2cnn, 2cno, 2cdr, 2h65, 1cp3, 1pau, 4pry – hCASP + polypeptide inhibitor
    
  • 4dcj, 4dco, 4dcp, 4eha, 4ehd, 4ehf, 4ehh, 4ehk, 4ehl, 4ehn, 4ps0, 4ps1 – hCASP subunits P12, P17 + polypeptide inhibitor
    
  • 2dko, 2cjx, 2cjy, 4qtx, 4qty, 4qu0, 4qu5, 4qu8, 4qu9, 4qua, 4qub 4qud, 4que, 4qug, 4quh, 4qui, 4quj, 4qul, 5i9b, 5i9t, 5iab, 5iae, 5iag, 5iaj, 5iak, 5ian, 5iar, 5ias, 5ibc, 5ibp, 5ibr, 4qud, 6bfj, 6bfk, 6bfl, 6bfo, 6bg0, 6bg1, 6bg4, 6bgk, 6bgq, 6bgr, 6bgs, 6bh9, 6bha, 6bdv - hCASP (mutant) + polypeptide inhibitor
    
  • 3kjf, 3h0e, 3deh, 3dei, 3dej, 3dek, 1re1, 1rhj, 1rhk, 1rhm, 1rhq, 1rhr, 1rhu, 1nme, 1nmq, 1nms, 1gfw – hCASP + inhibitor
    
  • 3itn, 2j30, 2j31, 2j32, 2j33, 2c1e, 2c2k, 2c2m, 2c2o, 2c2z, 2h5i, 2h5j, 4jr0 – hpro-CASP + polypeptide inhibitor
    

4jqy, 4jqz - hpro-CASP (mutant)

• • 1i3o - hCASP (mutant) + XIAP-BIR2
• CASP-6
  • 3p45, 3k7e, 2wdp – hCASP
    
  • 3nkf, 3nr2, 3s8e, 3v6l, 3v6m, 4iyr, 6dev, 6deu – hCASP (mutant)
    
  • 3od5, 3p4u, 3qnw, 3s70 – hCASP + polypeptide inhibitor
    
  • 4ejf – hCASP subunit P11 + P18 + polypeptide
    
  • 4fxo - hCASP subunit P11 + P18 + Zn
    
  • 4hva - hCASP subunit P11 + P18 + VEID inhibitor
    
  • 4n5d - hCASP subunit P11 + P18 + inhibitor
    
  • 4n6g, 4n7j, 4n7m, 4nbk, 4nbl, 4nbn - hCASP subunit P11 + P18 (mutant) + inhibitor
    
• CASP-7
  • 3rk5, 4fdl - hCASP
    
  • 5k20 – hCASP large + small (mutant) subunits
    
  • 3ibf – hCASP large subunit
    
  • 3r5k, 4hq0 - hCASP (mutant)
    
  • 1k86, 1gqf – hCASP catalytic domain
    
  • 1k88 – hpro-CASP (mutant)
    
  • 3ibc, 2ql5, 2ql7, 2ql9, 2qlb, 2qlf, 2qlj, 3edr - hCASP large subunit + polypeptide inhibitor
    
  • 1f1j, 4hqr - hCASP + polypeptide inhibitor
    
  • 3h1p, 4jr1, 4jr2 - hCASP catalytic domain (mutant) + polypeptide inhibitor
    
  • 1shj, 1shl - hCASP catalytic domain (mutant) + inhibitor
    
  • 4fea, 5v6z, 5v6u - hCASP catalytic domain + inhibitor
    
  • 1i51, 1kmc - hCASP (mutant) + XIAP-BIR2
    
  • 1i4o - hCASP P20 subunit + XIAP
    
  • 4jb8, 4lsz - hCASP large+small subunits + DARPIN
    
  • 5ic6, 5ic4, 4zvo, 4zvp, 4zvq, 4zvr, 4zvs, 4zvt, 4zvu, 6cl2, 6cl1, 6cl0, 6ckz - hCASP large+small subunits + peptide inhibitor
    
• CASP-8
  • 5l08 – hCASP – Cryo-EM
    
  • 4zbw - hCASP death effector domain
    
  • 5h33, 5h31 - hCASP death effector domain (mutant)
    
  • 3kjn, 3kjq – hCASP subunit P18 + inhibitor
    
  • 1f9e, 1qtn, 1qdu - hCASP subunit α,β + polypeptide inhibitor
    
  • 1qtn, 4jj7, 4jj8, 4prz - hCASP P18, P11 + polypeptide inhibitor
    
  • 3h11 - hCASP (mutant) + polypeptide inhibitor
    
  • 2y1l - hCASP subunits P18 P10
    
  • 2k7z – hpro-CASP (mutant) – NMR
    
  • 2fun, 1i4e – CASP + P35 – Autographa californica
• CASP-9
  • 2ar9 – hCASP (mutant)
    
  • 1jxq - hCASP + polypeptide inhibitor
    
  • 3v3k – hCASP + effector protein
    
  • 5wve, 5juy, 5wvc – hCASP CARD domain + APAF-1
    
  • 1nw9 – hCASP catalytic domain + XIAP-BIR3
    
  • 3ygs, 4rhw – hpro-CASP + APAF-1 CARD
• Drosophila melanogaster CASP
  • 2fp3 – DmCASP Dronc residues 136-450 – Drosophila melanogaster
    
  • 3sir - DmCASP drICE residues 78-332
    
  • 3sip – DmCASP drICE residues 78-230 + apoptosis inhibitor
    
• Metacaspase
  • 4afp, 4afr, 4afv, 4af8 – MCASP (mutant) – Trypanosom brucei
    
  • 4f6o – yMCASP 1 – yeast
    
  • 4f6p – yMCASP 1 (mutant)