6me3: Difference between revisions

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'''Unreleased structure'''


The entry 6me3 is ON HOLD  until Paper Publication
==XFEL crystal structure of human melatonin receptor MT1 in complex with 2-phenylmelatonin==
 
<StructureSection load='6me3' size='340' side='right'caption='[[6me3]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6me3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ME3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ME3 FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JEY:N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide'>JEY</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6me3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6me3 OCA], [http://pdbe.org/6me3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6me3 RCSB], [http://www.ebi.ac.uk/pdbsum/6me3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6me3 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/MTR1A_HUMAN MTR1A_HUMAN]] High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Batyuk, A]]
[[Category: Brehm, W]]
[[Category: Cherezov, V]]
[[Category: Gati, C]]
[[Category: Grandner, J M]]
[[Category: Grant, T D]]
[[Category: Han, G W]]
[[Category: Ishchenko, A]]
[[Category: Johansson, L C]]
[[Category: Katritch, V]]
[[Category: Liu, W]]
[[Category: Madsen, C]]
[[Category: McCorvy, J D]]
[[Category: Michaelian, N]]
[[Category: Olsen, R H.J]]
[[Category: Patel, N]]
[[Category: Roth, B L]]
[[Category: Stauch, B]]
[[Category: Tribo, A R]]
[[Category: Weierstall, U]]
[[Category: White, T A]]
[[Category: Zhu, L]]
[[Category: 2-phenylmelatonin]]
[[Category: Circadian rhythm]]
[[Category: Gpcr]]
[[Category: Jetlag]]
[[Category: Lcp]]
[[Category: Membrane protein]]
[[Category: Pg]]
[[Category: Xfel]]

Revision as of 09:57, 24 April 2019

XFEL crystal structure of human melatonin receptor MT1 in complex with 2-phenylmelatoninXFEL crystal structure of human melatonin receptor MT1 in complex with 2-phenylmelatonin

Structural highlights

6me3 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
NonStd Res:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[MTR1A_HUMAN] High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

6me3, resolution 2.90Å

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OCA
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