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==Human GKRP bound to AMG-3295 and Sorbitol-6-phosphate== | ==Human GKRP bound to AMG-3295 and Sorbitol-6-phosphate== | ||
<StructureSection load='4px3' size='340' side='right' caption='[[4px3]], [[Resolution|resolution]] 2.43Å' scene=''> | <StructureSection load='4px3' size='340' side='right'caption='[[4px3]], [[Resolution|resolution]] 2.43Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4px3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PX3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PX3 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4px3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PX3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PX3 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2WX:N-[(R)-1-BENZOTHIOPHEN-2-YL(2-CHLOROPHENYL)METHYL]-3,4-DIHYDRO-2H-1,5-BENZODIOXEPINE-7-SULFONAMIDE'>2WX</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=S6P:D-SORBITOL-6-PHOSPHATE'>S6P</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2WX:N-[(R)-1-BENZOTHIOPHEN-2-YL(2-CHLOROPHENYL)METHYL]-3,4-DIHYDRO-2H-1,5-BENZODIOXEPINE-7-SULFONAMIDE'>2WX</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=S6P:D-SORBITOL-6-PHOSPHATE'>S6P</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4px2|4px2]], [[4px5|4px5]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4px2|4px2]], [[4px5|4px5]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GCKR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4px3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4px3 OCA], [http://pdbe.org/4px3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4px3 RCSB], [http://www.ebi.ac.uk/pdbsum/4px3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4px3 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4px3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4px3 OCA], [http://pdbe.org/4px3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4px3 RCSB], [http://www.ebi.ac.uk/pdbsum/4px3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4px3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/GCKR_HUMAN GCKR_HUMAN]] Inhibits glucokinase by forming an inactive complex with this enzyme. | [[http://www.uniprot.org/uniprot/GCKR_HUMAN GCKR_HUMAN]] Inhibits glucokinase by forming an inactive complex with this enzyme. | ||
==See Also== | |||
*[[Glucokinase Regulatory Protein|Glucokinase Regulatory Protein]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | |||
[[Category: Chmait, S]] | [[Category: Chmait, S]] | ||
[[Category: Jordan, S R]] | [[Category: Jordan, S R]] | ||
Revision as of 11:05, 17 April 2019
Human GKRP bound to AMG-3295 and Sorbitol-6-phosphateHuman GKRP bound to AMG-3295 and Sorbitol-6-phosphate
Structural highlights
Function[GCKR_HUMAN] Inhibits glucokinase by forming an inactive complex with this enzyme. See Also |
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