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==First Crystal Structure for an Oxaliplatin-Protein Complex== | ==First Crystal Structure for an Oxaliplatin-Protein Complex== | ||
<StructureSection load='4ppo' size='340' side='right' caption='[[4ppo]], [[Resolution|resolution]] 1.73Å' scene=''> | <StructureSection load='4ppo' size='340' side='right'caption='[[4ppo]], [[Resolution|resolution]] 1.73Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ppo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PPO FirstGlance]. <br> | <table><tr><td colspan='2'>[[4ppo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PPO FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PT:CYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II)'>1PT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PT:CYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II)'>1PT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LYZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ppo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ppo OCA], [http://pdbe.org/4ppo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ppo RCSB], [http://www.ebi.ac.uk/pdbsum/4ppo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ppo ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ppo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ppo OCA], [http://pdbe.org/4ppo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ppo RCSB], [http://www.ebi.ac.uk/pdbsum/4ppo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ppo ProSAT]</span></td></tr> | ||
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</div> | </div> | ||
<div class="pdbe-citations 4ppo" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4ppo" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Lysozyme 3D structures|Lysozyme 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Chick]] | |||
[[Category: Large Structures]] | |||
[[Category: Lysozyme]] | [[Category: Lysozyme]] | ||
[[Category: Merlino, A]] | [[Category: Merlino, A]] | ||
Revision as of 10:30, 17 April 2019
First Crystal Structure for an Oxaliplatin-Protein ComplexFirst Crystal Structure for an Oxaliplatin-Protein Complex
Structural highlights
Function[LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.[1] Publication Abstract from PubMedThe X-ray structure of the adduct formed between oxaliplatin and the model protein hen egg white lysozyme is reported here. The structure is compared with those of cisplatin and carboplatin derivatives, previously solved. Relevant changes are highlighted among these crystal structures that are suggestive of significant differences in the reactivity of platinum drugs with this protein; possible biological implications are discussed. The X-ray structure of the complex formed in the reaction between oxaliplatin and lysozyme.,Messori L, Marzo T, Merlino A Chem Commun (Camb). 2014 Aug 7;50(61):8360-2. doi: 10.1039/c4cc02254h. PMID:24943911[2] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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