4m61: Difference between revisions
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==Crystal structure of unliganded anti-DNA Fab A52== | ==Crystal structure of unliganded anti-DNA Fab A52== | ||
<StructureSection load='4m61' size='340' side='right' caption='[[4m61]], [[Resolution|resolution]] 1.62Å' scene=''> | <StructureSection load='4m61' size='340' side='right'caption='[[4m61]], [[Resolution|resolution]] 1.62Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4m61]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M61 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4m61]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M61 FirstGlance]. <br> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Eilat, D]] | [[Category: Eilat, D]] | ||
Revision as of 12:34, 3 April 2019
Crystal structure of unliganded anti-DNA Fab A52Crystal structure of unliganded anti-DNA Fab A52
Structural highlights
Publication Abstract from PubMedA52 is a murine monoclonal antibody isolated from autoimmune New Zealand Black/New Zealand White F1 mice that recognizes single and double stranded DNA. This mouse strain spontaneously develops systemic lupus erythematosus-like symptoms and has served as a model for that disease for many years. The 1.62 A crystal structure of the A52 Fab fragment reveals an H3 complementarity determining region with four closely spaced arginine residues, creating a positively charged surface to accommodate bound DNA. Proteins 2014. (c) 2014 Wiley Periodicals, Inc. Crystal structure determination of anti-DNA Fab A52.,Stanfield RL, Eilat D Proteins. 2014 Jan 22. doi: 10.1002/prot.24514. PMID:24449198[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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