Flavodoxin: Difference between revisions

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[[Flavodoxin]] (FDX) is a bacterial protein which contains flavin mononucleotide (FMN) or flavin adenine dinucleotide (FAD).  It participates in nitrogen metabolism and reduces N<sub>2</sub> to NH<sub>3</sub> while changing from its oxidized quinone state FDX-ox via semiquinone FDX-sq to its reduced hydroquinone state FDX-red<ref>PMID:9416602</ref>.  '''NrdI''' is a FDX which is involved in ribonucleotide reduction.  '''WrbA (Tryptophan Repressor-Binding Protein)''' is also FDX.  In ''E. coli'' there are 2 distinct flavodoxins: FDX I and II.
[[Flavodoxin]] (FDX) is a bacterial protein which contains flavin mononucleotide (FMN) or flavin adenine dinucleotide (FAD).  It participates in nitrogen metabolism and reduces N<sub>2</sub> to NH<sub>3</sub> while changing from its oxidized quinone state FDX-ox via semiquinone FDX-sq to its reduced hydroquinone state FDX-red<ref>PMID:9416602</ref>.  '''NrdI''' is a FDX which is involved in ribonucleotide reduction.  '''WrbA (Tryptophan Repressor-Binding Protein)''' is also FDX.  In ''E. coli'' there are 2 distinct flavodoxins: FDX I and II.


*<scene name='41/413119/Cv/3'>Apo-Flavodoxin from Helicobacter pylori complexed with benzamidine and chloride ion</scene>.
*<scene name='41/413119/Cv/5'>Apo-Flavodoxin from Helicobacter pylori complexed with benzamidine and chloride ion</scene>.
*<scene name='41/413119/Cv/4'>Cl coordination site</scene>. Water molecules shown as red spheres.
*<scene name='41/413119/Cv/6'>Cl coordination site</scene>. Water molecules shown as red spheres.
    
    
</StructureSection>
</StructureSection>

Revision as of 15:49, 28 March 2019


Flavodoxin (FDX) is a bacterial protein which contains flavin mononucleotide (FMN) or flavin adenine dinucleotide (FAD). It participates in nitrogen metabolism and reduces N2 to NH3 while changing from its oxidized quinone state FDX-ox via semiquinone FDX-sq to its reduced hydroquinone state FDX-red[1]. NrdI is a FDX which is involved in ribonucleotide reduction. WrbA (Tryptophan Repressor-Binding Protein) is also FDX. In E. coli there are 2 distinct flavodoxins: FDX I and II.

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  • . Water molecules shown as red spheres.


Apo-Flavodoxin from Helicobacter pylori complexed with benzamidine and chloride ion (PDB code 2bmv)

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3D Structures of Flavodoxin3D Structures of Flavodoxin

Updated on 28-March-2019

ReferencesReferences

  1. Hoover DM, Ludwig ML. A flavodoxin that is required for enzyme activation: the structure of oxidized flavodoxin from Escherichia coli at 1.8 A resolution. Protein Sci. 1997 Dec;6(12):2525-37. PMID:9416602 doi:10.1002/pro.5560061205

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Alexander Berchansky, Michal Harel, Jaime Prilusky