4e13: Difference between revisions
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==Substrate-directed dual catalysis of dicarbonyl compounds by diketoreductase== | ==Substrate-directed dual catalysis of dicarbonyl compounds by diketoreductase== | ||
<StructureSection load='4e13' size='340' side='right' caption='[[4e13]], [[Resolution|resolution]] 2.08Å' scene=''> | <StructureSection load='4e13' size='340' side='right'caption='[[4e13]], [[Resolution|resolution]] 2.08Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4e13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acinetobacter_baylyi Acinetobacter baylyi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E13 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4e13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acinetobacter_baylyi Acinetobacter baylyi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E13 FirstGlance]. <br> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Acinetobacter baylyi]] | [[Category: Acinetobacter baylyi]] | ||
[[Category: Large Structures]] | |||
[[Category: Chen, Y]] | [[Category: Chen, Y]] | ||
[[Category: Cheng, X]] | [[Category: Cheng, X]] | ||
Revision as of 10:45, 27 March 2019
Substrate-directed dual catalysis of dicarbonyl compounds by diketoreductaseSubstrate-directed dual catalysis of dicarbonyl compounds by diketoreductase
Structural highlights
Publication Abstract from PubMedDiketoreductase catalyzes a two-step bioreduction on a dicarbonyl substrate through a novel dual catalysis mode, in which random hydride attack simultaneously forms two mono-carbonyl intermediates, and subsequently distinct catalytic sites are responsible for the reductions of respective carbonyl group of the intermediates to yield the final dihydroxy product. Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase.,Lu M, Huang Y, White MA, Wu X, Liu N, Cheng X, Chen Y Chem Commun (Camb). 2012 Oct 24;48(92):11352-4. doi: 10.1039/c2cc36334h. PMID:23073461[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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