6huf: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
m Protected "6huf" [edit=sysop:move=sysop]
No edit summary
Line 1: Line 1:
'''Unreleased structure'''


The entry 6huf is ON HOLD
==Coping with strong translational non-crystallographic symmetry and extreme anisotropy in molecular replacement with Phaser: human Rab27a==
 
<StructureSection load='6huf' size='340' side='right'caption='[[6huf]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
Authors: Jamshidiha, M., Perez-Dorado, I., Murray, J.W., Tate, E.W., Cota, E., Read, R.J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6huf]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HUF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HUF FirstGlance]. <br>
Description: Coping with strong translational non-crystallographic symmetry and extreme anisotropy in molecular replacement with Phaser: human Rab27a
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6huf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6huf OCA], [http://pdbe.org/6huf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6huf RCSB], [http://www.ebi.ac.uk/pdbsum/6huf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6huf ProSAT]</span></td></tr>
[[Category: Read, R.J]]
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/RB27A_HUMAN RB27A_HUMAN]] Griscelli syndrome type 2. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[[http://www.uniprot.org/uniprot/RB27A_HUMAN RB27A_HUMAN]] Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.<ref>PMID:18812475</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Cota, E]]
[[Category: Cota, E]]
[[Category: Murray, J.W]]
[[Category: Tate, E.W]]
[[Category: Jamshidiha, M]]
[[Category: Jamshidiha, M]]
[[Category: Murray, J W]]
[[Category: Perez-Dorado, I]]
[[Category: Perez-Dorado, I]]
[[Category: Read, R J]]
[[Category: Tate, E W]]
[[Category: Exocytosis]]
[[Category: Gtpase]]
[[Category: Vesicle transport]]

Revision as of 09:39, 27 March 2019

Coping with strong translational non-crystallographic symmetry and extreme anisotropy in molecular replacement with Phaser: human Rab27aCoping with strong translational non-crystallographic symmetry and extreme anisotropy in molecular replacement with Phaser: human Rab27a

Structural highlights

6huf is a 16 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[RB27A_HUMAN] Griscelli syndrome type 2. The disease is caused by mutations affecting the gene represented in this entry.

Function

[RB27A_HUMAN] Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.[1]

References

  1. ↑ Menasche G, Menager MM, Lefebvre JM, Deutsch E, Athman R, Lambert N, Mahlaoui N, Court M, Garin J, Fischer A, de Saint Basile G. A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion. Blood. 2008 Dec 15;112(13):5052-62. doi: 10.1182/blood-2008-02-141069. Epub 2008 , Sep 23. PMID:18812475 doi:http://dx.doi.org/10.1182/blood-2008-02-141069

6huf, resolution 2.82Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=6huf&oldid=3017674"