6fu6: Difference between revisions
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==Phosphotriesterase PTE_C23_2== | |||
<StructureSection load='6fu6' size='340' side='right'caption='[[6fu6]], [[Resolution|resolution]] 1.95Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6fu6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FU6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FU6 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=TA8:POLYACRYLIC+ACID'>TA8</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6fee|6fee]], [[6fef|6fef]], [[6fei|6fei]], [[6fev|6fev]], [[6ffw|6ffw]], [[6for|6for]], [[6frz|6frz]], [[6fqe|6fqe]], [[6fs3|6fs3]], [[6fu0|6fu0]]</td></tr> | ||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aryldialkylphosphatase Aryldialkylphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.1 3.1.8.1] </span></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fu6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fu6 OCA], [http://pdbe.org/6fu6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fu6 RCSB], [http://www.ebi.ac.uk/pdbsum/6fu6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fu6 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/OPD_BREDI OPD_BREDI]] Has an unusual substrate specificity for synthetic organophosphate triesters and phosphorofluoridates. All of the phosphate triesters found to be substrates are synthetic compounds. The identity of any naturally occurring substrate for the enzyme is unknown. Has no detectable activity with phosphate monoesters or diesters and no activity as an esterase or protease. It catalyzes the hydrolysis of the insecticide paraoxon at a rate approaching the diffusion limit and thus appears to be optimally evolved for utilizing this synthetic substrate. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Aryldialkylphosphatase]] | |||
[[Category: Large Structures]] | |||
[[Category: Aggarwal, N]] | |||
[[Category: Albeck, S]] | [[Category: Albeck, S]] | ||
[[Category: | [[Category: Ashani, Y]] | ||
[[Category: | [[Category: Dym, O]] | ||
[[Category: Goldsmith, M]] | |||
[[Category: Greisen, P]] | [[Category: Greisen, P]] | ||
[[Category: | [[Category: Leader, H]] | ||
[[Category: | [[Category: Rogotner, S Hamer]] | ||
[[Category: Silman, I]] | [[Category: Silman, I]] | ||
[[Category: Sussman, L J]] | |||
[[Category: Tawfik, D]] | [[Category: Tawfik, D]] | ||
[[Category: | [[Category: Unger, T]] | ||
[[Category: | [[Category: Hydrolase]] | ||
[[Category: Metalloenzyme]] | |||
[[Category: Tim barrel]] | |||
Latest revision as of 10:51, 20 March 2019
Phosphotriesterase PTE_C23_2Phosphotriesterase PTE_C23_2
Structural highlights
Function[OPD_BREDI] Has an unusual substrate specificity for synthetic organophosphate triesters and phosphorofluoridates. All of the phosphate triesters found to be substrates are synthetic compounds. The identity of any naturally occurring substrate for the enzyme is unknown. Has no detectable activity with phosphate monoesters or diesters and no activity as an esterase or protease. It catalyzes the hydrolysis of the insecticide paraoxon at a rate approaching the diffusion limit and thus appears to be optimally evolved for utilizing this synthetic substrate. |
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