Exportin: Difference between revisions
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<StructureSection load='3icq' size='400' side='right' caption='Structure of yeast exportin-5 (magenta) complex with GTPaseRan (cyan), Mg+2 (green) and RNA (PDB code [[3icq]]).' scene='59/592125/Cv/ | <StructureSection load='3icq' size='400' side='right' caption='Structure of yeast exportin-5 (magenta) complex with GTPaseRan (cyan), Mg+2 (green) and RNA (PDB code [[3icq]]).' scene='59/592125/Cv/9'> | ||
'''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. '''XPO-t''' exports tRNA from the nucleus<ref>PMID:17786152</ref>. | '''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. '''XPO-t''' exports tRNA from the nucleus<ref>PMID:17786152</ref>. | ||
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==Structural highlights == | ==Structural highlights == | ||
<scene name='59/592125/Cv/ | <scene name='59/592125/Cv/10'>Yeast exportin-5 with GTPaseRan, Mg+2 and RNA</scene>. | ||
<scene name='59/592125/Cv/ | <scene name='59/592125/Cv/11'>GTP binding site</scene>. | ||
<scene name='59/592125/Cv/ | <scene name='59/592125/Cv/12'>Mg coordination site</scene> (PDB code [[3icq]]).<ref>PMID:19680239</ref> | ||
</StructureSection> | </StructureSection> | ||