1oll: Difference between revisions
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==Extracellular region of the human receptor NKp46== | ==Extracellular region of the human receptor NKp46== | ||
<StructureSection load='1oll' size='340' side='right' caption='[[1oll]], [[Resolution|resolution]] 1.93Å' scene=''> | <StructureSection load='1oll' size='340' side='right' caption='[[1oll]], [[Resolution|resolution]] 1.93Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1oll]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OLL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OLL FirstGlance]. <br> | <table><tr><td colspan='2'>[[1oll]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OLL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OLL FirstGlance]. <br> | ||
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</div> | </div> | ||
<div class="pdbe-citations 1oll" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 1oll" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[NK cell receptor|NK cell receptor]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 10:42, 6 March 2019
Extracellular region of the human receptor NKp46Extracellular region of the human receptor NKp46
Structural highlights
Function[NCTR1_HUMAN] Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.[1] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedNKp46, a natural killer (NK) cell-specific receptor, has been recently identified as one of the triggering receptors involved in NK cell activation mediated by non-HLA class I ligands. The structure of the NKp46 extracellular receptor region, here reported, consists of two Ig-like domains assembled similarly to leukocyte immunoglobulin-like receptors (LIRs) and killer inhibitory receptors (KIRs). The extensive NKp46 residue substitutions at sites structurally related to those mediating interaction with HLA antigens in LIRs and KIRs indicate that NKp46 recognition processes in vivo should involve non-HLA ligands. NKP46 is shown to stem from an ancestral KIR/LIR family. However, the absence of close paralogues, such as those found for LIR and KIR, indicates that NKp46 is the unique member of a distinct Ig-like subfamily and suggests a specific role, which appears to be maintained across primates and rodents. Structure of the human NK cell triggering receptor NKp46 ectodomain.,Ponassi M, Cantoni C, Biassoni R, Conte R, Spallarossa A, Pesce A, Moretta A, Moretta L, Bolognesi M, Bordo D Biochem Biophys Res Commun. 2003 Sep 19;309(2):317-23. PMID:12951052[2] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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