Dopamine receptor: Difference between revisions

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Erin Elizabeth Sherman, Michal Harel, Jaime Prilusky, Alexander Berchansky, Joel L. Sussman

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 *Clebopride<ref>Cuena Boy R, Maciá Martínez MA (1998). "[Extrapyramidal toxicity caused by metoclopramide and clebopride: study of voluntary notifications of adverse effects to the Spanish Drug Surveillance System]" (in Spanish). Atencion Primaria 21 (5): 289–95. PMID 9608114.  Free full text</ref>
 *Nafadotride<ref>Pilla M, Perachon S, Sautel F, Garrido F, Mann A, Wermuth CG, Schwartz JC, Everitt BJ, Sokoloff P. Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 agonist. Nature. 1999;400:371–375.</ref>
-Two ligands that are associated with the dopamine D3 receptor are 3-chloro-5-ethyl-N{[(2S)-1-ethylpyrrolidin-2-yl]methyl}-6-hydroxyl-2-methyloxybenzamide <scene name='47/475982/Cv/2'>(eticlopride, ETQ)</scene> and <scene name='47/475982/Cv/3'>maltose</scene> (MAL).  ETQ binds to dopamine D3 receptor by Asp 110 and Phe346. MAL binds by Asp 1020, Glu 1022, Glu1011, and Leu1032. Of note, this structure ([[3pbl]]) is chimeric between dopamine D3 receptor and Lysozyme, MAL binds only to Lysozyme part of this chimera. <ref name="structure" /> <scene name='47/475982/Cv/4'>So, MAL cannot be the real ligand of dopamine D3 receptor</scene>.
+Two ligands that are associated with the dopamine D3 receptor are 3-chloro-5-ethyl-N{[(2S)-1-ethylpyrrolidin-2-yl]methyl}-6-hydroxyl-2-methyloxybenzamide <scene name='47/475982/Cv/5'>(eticlopride, ETQ)</scene> and <scene name='47/475982/Cv/6'>maltose</scene> (MAL).  ETQ binds to dopamine D3 receptor by Asp 110 and Phe346. MAL binds by Asp 1020, Glu 1022, Glu1011, and Leu1032. Of note, this structure ([[3pbl]]) is chimeric between dopamine D3 receptor and Lysozyme, MAL binds only to Lysozyme part of this chimera. <ref name="structure" /> <scene name='47/475982/Cv/7'>So, MAL cannot be the real ligand of dopamine D3 receptor</scene>.
 ==Diseases==