6nb8: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6nb8 is ON HOLD  until Paper Publication
+==Crystal structure of anti- SARS-CoV human neutralizing S230 antibody Fab fragment==
+<StructureSection load='6nb8' size='340' side='right' caption='[[6nb8]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6nb8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NB8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NB8 FirstGlance]. <br>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nb8 OCA], [http://pdbe.org/6nb8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nb8 RCSB], [http://www.ebi.ac.uk/pdbsum/6nb8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nb8 ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Recent outbreaks of severe acute respiratory syndrome and Middle East respiratory syndrome, along with the threat of a future coronavirus-mediated pandemic, underscore the importance of finding ways to combat these viruses. The trimeric spike transmembrane glycoprotein S mediates entry into host cells and is the major target of neutralizing antibodies. To understand the humoral immune response elicited upon natural infections with coronaviruses, we structurally characterized the SARS-CoV and MERS-CoV S glycoproteins in complex with neutralizing antibodies isolated from human survivors. Although the two antibodies studied blocked attachment to the host cell receptor, only the anti-SARS-CoV S antibody triggered fusogenic conformational changes via receptor functional mimicry. These results provide a structural framework for understanding coronavirus neutralization by human antibodies and shed light on activation of coronavirus membrane fusion, which takes place through a receptor-driven ratcheting mechanism.
-Authors:
+Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion.,Walls AC, Xiong X, Park YJ, Tortorici MA, Snijder J, Quispe J, Cameroni E, Gopal R, Dai M, Lanzavecchia A, Zambon M, Rey FA, Corti D, Veesler D Cell. 2019 Jan 23. pii: S0092-8674(18)31642-8. doi: 10.1016/j.cell.2018.12.028. PMID:30712865<ref>PMID:30712865</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 6nb8" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Human]]
+[[Category: Cameroni, E]]
+[[Category: Corti, D]]
+[[Category: Dai, M]]
+[[Category: Gopal, R]]
+[[Category: Lanzavecchia, A]]
+[[Category: Park, Y J]]
+[[Category: Quispe, J]]
+[[Category: Rey, F A]]
+[[Category: Structural genomic]]
+[[Category: Snijder, J]]
+[[Category: Tortorici, M A]]
+[[Category: Veesler, D]]
+[[Category: Walls, A J]]
+[[Category: Xiong, X]]
+[[Category: Zambon, M]]
+[[Category: Coronavirus]]
+[[Category: Fab]]
+[[Category: Glycoprotein]]
+[[Category: Immune system]]
+[[Category: Sar]]
+[[Category: Ssgcid]]