6nb4: Difference between revisions
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The entry | ==MERS-CoV S complex with human neutralizing LCA60 antibody Fab fragment (state 2)== | ||
<StructureSection load='6nb4' size='340' side='right' caption='[[6nb4]], [[Resolution|resolution]] 3.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6nb4]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Mers Mers]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NB4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NB4 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6nb3|6nb3]], [[6nb5|6nb5]], [[6nb6|6nb6]], [[6nb7|6nb7]], [[6nb8|6nb8]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nb4 OCA], [http://pdbe.org/6nb4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nb4 RCSB], [http://www.ebi.ac.uk/pdbsum/6nb4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nb4 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Recent outbreaks of severe acute respiratory syndrome and Middle East respiratory syndrome, along with the threat of a future coronavirus-mediated pandemic, underscore the importance of finding ways to combat these viruses. The trimeric spike transmembrane glycoprotein S mediates entry into host cells and is the major target of neutralizing antibodies. To understand the humoral immune response elicited upon natural infections with coronaviruses, we structurally characterized the SARS-CoV and MERS-CoV S glycoproteins in complex with neutralizing antibodies isolated from human survivors. Although the two antibodies studied blocked attachment to the host cell receptor, only the anti-SARS-CoV S antibody triggered fusogenic conformational changes via receptor functional mimicry. These results provide a structural framework for understanding coronavirus neutralization by human antibodies and shed light on activation of coronavirus membrane fusion, which takes place through a receptor-driven ratcheting mechanism. | |||
Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion.,Walls AC, Xiong X, Park YJ, Tortorici MA, Snijder J, Quispe J, Cameroni E, Gopal R, Dai M, Lanzavecchia A, Zambon M, Rey FA, Corti D, Veesler D Cell. 2019 Jan 23. pii: S0092-8674(18)31642-8. doi: 10.1016/j.cell.2018.12.028. PMID:30712865<ref>PMID:30712865</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6nb4" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Human]] | |||
[[Category: Mers]] | |||
[[Category: Cameroni, E]] | |||
[[Category: Corti, D]] | |||
[[Category: Gopal, R]] | |||
[[Category: Lanzavecchia, A]] | |||
[[Category: Mian, D]] | |||
[[Category: Park, Y J]] | |||
[[Category: Quispe, J]] | |||
[[Category: Rey, F A]] | |||
[[Category: Structural genomic]] | |||
[[Category: Snijder, S]] | |||
[[Category: Tortorici, M A]] | |||
[[Category: Veesler, D]] | |||
[[Category: Walls, A C]] | |||
[[Category: Xiong, X]] | |||
[[Category: Zambon, M]] | |||
[[Category: Coronavirus spike glycoprotein]] | |||
[[Category: Human neutralizing antibody]] | |||
[[Category: Mers-cov]] | |||
[[Category: Sars-cov]] | |||
[[Category: Ssgcid]] | |||
[[Category: Virus]] | |||