6-deoxyerythronolide B synthase (DEBS): Difference between revisions
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TE is the terminal domain in DEBS, releasing the completed polyketide from the synthase by forming a 14-membered lactone. It is able to close such a large ring by threading it into a large inner cavity which stabilizes its conformation while esterification occurs. | TE is the terminal domain in DEBS, releasing the completed polyketide from the synthase by forming a 14-membered lactone. It is able to close such a large ring by threading it into a large inner cavity which stabilizes its conformation while esterification occurs. | ||
==3D structures of 6-deoxyerythronolide B synthase== | |||
[[6-deoxyerythronolide B synthase 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
==3D structures of 6-deoxyerythronolide B synthase== | ==3D structures of 6-deoxyerythronolide B synthase== | ||
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**[[2hg4]] – yDEBS ketosynthase-acyltransferase didomain of module 5 - yeast <br /> | **[[2hg4]] – yDEBS ketosynthase-acyltransferase didomain of module 5 - yeast <br /> | ||
**[[2qo3]] – SeDEBS module 3 – ''Sacchropolyspora erythraea''<br /> | **[[2qo3]] – SeDEBS module 3 – ''Sacchropolyspora erythraea''<br /> | ||
**[[6c9u]] – SeDEBS module 3 + antibody<br /> | |||
**[[6mlk]] – SeDEBS module 5,6 + antibody<br /> | |||
*DEBS1 | *DEBS1 | ||