6dks: Difference between revisions
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<StructureSection load='6dks' size='340' side='right' caption='[[6dks]], [[Resolution|resolution]] 2.78Å' scene=''> | <StructureSection load='6dks' size='340' side='right' caption='[[6dks]], [[Resolution|resolution]] 2.78Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6dks]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DKS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DKS FirstGlance]. <br> | <table><tr><td colspan='2'>[[6dks]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Eco57 Eco57] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DKS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DKS FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rbpj, Igkjrb1, Igkrsbp, Rbpsuh ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), malE, Z5632, ECs5017 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dks OCA], [http://pdbe.org/6dks PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dks RCSB], [http://www.ebi.ac.uk/pdbsum/6dks PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dks ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dks OCA], [http://pdbe.org/6dks PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dks RCSB], [http://www.ebi.ac.uk/pdbsum/6dks PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dks ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Eco57]] | |||
[[Category: Lk3 transgenic mice]] | |||
[[Category: Kovall, R A]] | [[Category: Kovall, R A]] | ||
[[Category: VanderWielen, B D]] | [[Category: VanderWielen, B D]] | ||
Revision as of 11:36, 21 February 2019
Structure of the Rbpj-SHARP-DNA Repressor ComplexStructure of the Rbpj-SHARP-DNA Repressor Complex
Structural highlights
Function[MALE_ECO57] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity). [SUH_MOUSE] Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA.[1] References
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