6etu: Difference between revisions

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'''Unreleased structure'''


The entry 6etu is ON HOLD  until Paper Publication
==Crystal structure of KDM4D with tetrazolhydrazide compound 7==
 
<StructureSection load='6etu' size='340' side='right' caption='[[6etu]], [[Resolution|resolution]] 1.33&Aring;' scene=''>
Authors: Malecki, P.H., Link, A., Weiss, M.S., Heinemann, U.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6etu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ETU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ETU FirstGlance]. <br>
Description: Crystal structure of KDM4D with tetrazolylhydrazide ligand Cn1
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BWZ:[[3-(2~{H}-1,2,3,4-tetrazol-5-yl)phenyl]carbonylamino]azanium'>BWZ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6etu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6etu OCA], [http://pdbe.org/6etu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6etu RCSB], [http://www.ebi.ac.uk/pdbsum/6etu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6etu ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/KDM4D_HUMAN KDM4D_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Heinemann, U]]
[[Category: Link, A]]
[[Category: Link, A]]
[[Category: Heinemann, U]]
[[Category: Malecki, P H]]
[[Category: Weiss, M.S]]
[[Category: Weiss, M S]]
[[Category: Malecki, P.H]]
[[Category: Cancer]]
[[Category: Epigenetic]]
[[Category: Inhibitor design]]
[[Category: Kdm4d]]
[[Category: Ligand binding]]
[[Category: Oxidoreductase]]
[[Category: Tetrazole]]
[[Category: Tetrazolylhydrazide]]

Revision as of 09:40, 21 February 2019

Crystal structure of KDM4D with tetrazolhydrazide compound 7Crystal structure of KDM4D with tetrazolhydrazide compound 7

Structural highlights

6etu is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[KDM4D_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.[1]

References

  1. ↑ Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y. Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell. 2006 May 5;125(3):467-81. Epub 2006 Apr 6. PMID:16603238 doi:10.1016/j.cell.2006.03.028

6etu, resolution 1.33Å

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