Collagenase (non-MMP): Difference between revisions

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== Structural highlights ==
== Structural highlights ==


''Clostridium histolycum'' collagenase contains several domains among them: peptidase domain (residues 331-721), polycystic kidney disease domain (PKD residues 792-880), collagen-binding domain (CBD residues 1003-1118). The peptidase domain contains a <scene name='47/477092/Cv/3'>Zn+2 coordination site</scene>, a <scene name='47/477092/Cv/4'>substrate-recognition site</scene> and an <scene name='47/477092/Cv/6'>oxyanion hole</scene>.<ref>PMID:23703618</ref> <scene name='47/477092/Cv/7'>Click here to see surface of binding site</scene>.
''Clostridium histolycum'' collagenase contains several domains among them: peptidase domain (residues 331-721), polycystic kidney disease domain (PKD residues 792-880), collagen-binding domain (CBD residues 1003-1118). The peptidase domain contains a <scene name='47/477092/Cv/8'>Zn+2 coordination site</scene>, a <scene name='47/477092/Cv/9'>substrate-recognition site</scene> and an <scene name='47/477092/Cv/10'>oxyanion hole</scene>.<ref>PMID:23703618</ref> Water molecules are shown as red spheres. <scene name='47/477092/Cv/11'>Click here to see surface of binding site</scene>.


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Michal Harel, Alexander Berchansky