6nn6: Difference between revisions

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-'''Unreleased structure'''
-The entry 6nn6 is ON HOLD
+==Structure of Dot1L-H2BK120ub nucleosome complex==
+<StructureSection load='6nn6' size='340' side='right' caption='[[6nn6]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
-Authors: Anderson, C.J., Baird, M.R., Hsu, A., Barbour, E.H., Koyama, Y., Borgnia, M.J., McGinty, R.K.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6nn6]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NN6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NN6 FirstGlance]. <br>
-Description: Structure of Dot1L-H2BK120ub nucleosome complex
+</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nn6 OCA], [http://pdbe.org/6nn6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nn6 RCSB], [http://www.ebi.ac.uk/pdbsum/6nn6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nn6 ProSAT]</span></td></tr>
-[[Category: Mcginty, R.K]]
+</table>
-[[Category: Anderson, C.J]]
+== Function ==
+[[http://www.uniprot.org/uniprot/H2A1_XENLA H2A1_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN]] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. [[http://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H32_XENLA H32_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H2B11_XENLA H2B11_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
+__TOC__
+</StructureSection>
+[[Category: Histone-lysine N-methyltransferase]]
+[[Category: Anderson, C J]]
+[[Category: Baird, M R]]
+[[Category: Barbour, E H]]
+[[Category: Borgnia, M J]]
+[[Category: Hsu, A]]
 [[Category: Koyama, Y]]
-[[Category: Baird, M.R]]
+[[Category: McGinty, R K]]
-[[Category: Borgnia, M.J]]
+[[Category: Chromatin]]
-[[Category: Barbour, E.H]]
+[[Category: Cryo-em]]
-[[Category: Hsu, A]]
+[[Category: Dot1l]]
+[[Category: Gene regulation]]
+[[Category: Histone methyltransferase]]
+[[Category: Nucleosome]]
+[[Category: Single particle]]
+[[Category: Structural biology]]