6am3: Difference between revisions
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The | ==Regulator of G protein signaling (RGS) 17 in complex with Ca2+== | ||
<StructureSection load='6am3' size='340' side='right' caption='[[6am3]], [[Resolution|resolution]] 1.53Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6am3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AM3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AM3 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6am3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6am3 OCA], [http://pdbe.org/6am3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6am3 RCSB], [http://www.ebi.ac.uk/pdbsum/6am3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6am3 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/RGS17_HUMAN RGS17_HUMAN]] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Lyon, A M]] | |||
[[Category: Sieng, M]] | |||
[[Category: G protein]] | |||
[[Category: Regulator]] | |||
[[Category: Signaling]] | |||
[[Category: Signaling protein]] | |||
Revision as of 12:26, 13 February 2019
Regulator of G protein signaling (RGS) 17 in complex with Ca2+Regulator of G protein signaling (RGS) 17 in complex with Ca2+
Structural highlights
Function[RGS17_HUMAN] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). |
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