Immunodeficiency virus protease 3D structures

Immunodeficiency virus protease 3D structuresImmunodeficiency virus protease 3D structures

Updated on 09-February-2019

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• HIV-I protease
  • 4yob, 4npu, 3u71, 2g69, 1lv1, 1odx – HIVP (mutant) – HIV-I virus
    
  • 2hvp, 1odw, 3phv – HIVP
    
  • 5uov, 5upz, 5ult, 5bry, 5bs4, 4mc1, 4mc2, 4mc6, 4mc9, 2q3k, 3th9 5ult – HIVP (mutant) + sulfonamide inhibitor
    
  • 3qrm, 3qpj, 3qbf, 3ckt, 3qro, 3qrs, 4gb2 – HIVP (mutant) + pyrrolidine inhibitor
    
  • 1hte, 1htf, 1htg – HIVP + penicillin inhibitor
    
  • 5kqx, 5kqy, 5kqz, 5kr0, 5kr1, 5kr2, 5b18, 4ll3, 4jec, 3tkg, 3tkw, 3tl9 – HIVP + drug
    
  • 5t8h, 5e5j, 5e5k, 4yoa, 4q5m, 3swj, 4npt, 4qgi, 3s43, 3s45, 3s53, 3s54, 3s56, 3d1x, 3cyw, 3cyx, 3d1z, 3d20, 3bvb, 2r5p, 2r5q, 2hs1, 2hs2, 2q5k, 2nmy, 2nmz, 2nnk, 2nnp, 2fxe, 2o4l, 2o4s, 2fgu, 2fgv, 3so9, 3spk, 3k4v, 1fb7, 2fxd, 2fxe, 3el4, 3el5, 3el9, 2z54 – HIVP (mutant) + drug
    
  • 4u7q, 4u7v, 4u8w, 4i8z, 4i8w, 3t11, 4fe6, 4a6b, 4a6c, 4dfg, 4dqb, 3gga, 3ggx, 2pwc, 2pwr, 2qnn, 2fde, 3kfr, 3kfs, 3tlh, 1hiv, 1hps, 1hpv, 1hvi, 1hvj, 1hvk, 1hvl, 1sbg, 1sh9, 1upj, 1w5v, 2uxz, 2uy0, 2zga, 3dcr, 3s85, 3zps, 3zpt, 3zpu, 4phv, 9hvp, 1c6x, 1c6y, 1c6z, 1c70, 1hxb, 2a4f, 1hos, 5ivq, 5ivr, 5ivs, 5ivt, 2upj – HIVP + inhibitor
    
  • 5jfp, 5jfu, 5jg1, 5kao, 5dgu, 5dgw, 5agz, 5ah6, 5ah8, 5ah9, 5aha, 5ahb, 5ahc, 5ah7, 4cpq, 4cpr, 4cps, 4cpt, 4cpu, 4cpw, 4cpx, 4coe, 4cp7, 4m8x, 4m8y, 3vf5, 3vf7, 3vfa, 3vfb, 4a4q, 3tof, 3tog, 3toh, 4djo, 4djp, 4djq, 4djr, 3sa3, 3sa4, 3sa5, 3sa6, 3sa7, 3sa8, 3sa9, 3saa, 3sab, 3sac, 4dqc, 4dqe, 4dqf, 4dqg, 4dqh, 3qrm, 3qro, 3qrs, 3qp0, 3qpj, 3qn8, 3qih, 3qbf, 3qaa, 3h5b, 3dk1, 3djk, 2r43, 3d1y, 2qci, 2qd6, 2qd7, 2qd8, 2qhy, 2qhz, 2qi1, 2qi7, 2z4o, 3bva, 3bxr, 3bxs, 2q54, 2j9j, 2j9k, 2je4, 2hc0, 2psu, 2psv, 2i0a, 2i0d, 2f3k, 2idw, 2ien, 2ieo, 2hb3, 1zbg, 2f80, 2f81, 2f8g, 2azc, 2a1e, 2fdd, 2aoc, 2aod, 2aoe, 1w5w, 1w5x, 1w5y, 3i7e, 1bdq, 1bwa, 1bwb, 1gnm, 1gnn, 1mrx, 1msn, 1sgu, 1t7i, 2pk5, 2pk6, 2r38, 2r3t, 3fx5, 3h5b, 3i6o, 3kdb, 3kdc, 3kdd, 3ok9, 3qaa, 3st5, 4hdb, 4hdf, 4hdp, 4he9, 4heg, 4kb9, 4zip, 5cok, 5con, 5coo, 5cop, 2xye, 2xyf, 4zls, 1axa, 1hef, 1heg, 1a8k, 1aaq – HIVP (mutant) + inhibitor
    
  • 2zye – HIVP (mutant) + inhibitor - neutron
    
• HIV-I protease complex with peptide
  • 4tvg, 5hvp – HIVP + pepstatin peptide
    
  • 4f73, 4f74, 4f75, 4f76, 4ep2, 4ep3, 4epj, 4eq0, 4eqj – HIVP + substrate peptide
    
  • 4fae, 4faf, 2fns, 2fnt, 1f7a, 1kj4, 1kj7, 1kjf, 1kjg, 1kjh, 1tsq, 1tsu, 2aof, 2aog, 2aoh, 5yrs, 3d3t – HIVP (mutant) + substrate peptide
    
  • 4qj2, 4qj6, 4qj7, 4qj8, 4qj9, 4qja, 4fl8, 4flg, 4fm6, 4e43, 3b7v, 3b80, 2nxd, 2nxl, 2nxm, 4gzf – HIVP (mutant) + peptide
    
  • 1zsr, 1hbv – HIVP + peptidomimetic inhibitor
    
  • 1lzq, 1z8c, 1zbg, 1zj7, 1zpk – HIVP (mutant) + peptidomimetic inhibitor
    
  • 4i3s, 4i3r – HIVP Gp120 + antibody
    
• Drug resistant HIV-I protease
  • 4z4x, 4z50, 5t2e, 4q1w, 4q1x, 4q1y, 4qlh, 4nkk, 3uf3, 2avm, 2avo, 2avq, 2avs, 2avv, 3oq7, 3oqa, 3oqd, 3pj6, 1rpi, 1rq9, 1tw7 – HIVP (mutant)
    
  • 4ye3, 4yhq, 4rvi, 4rvx, 4njs, 4j54, 4j55, 3t3c, 3r0w, 3r0y, 2p3a, 2p3b, 2p3c, 2p3d, 1bv7, 1hvs, 1n49 – HIVP (mutant) + inhibitor
    
  • 4rvj – HIVP + drug
    
  • 5t2z, 4l1a, 4njt, 4nju, 4njv, 4j5j, 4eyr, 3ttp, 3ucb, 3ufn, 3u7s, 3uhl, 3ekp, 3ekq, 3ekt, 3ekv, 3ekw, 3eky, 3el0, 3el5, 3el9, 3em3, 3em4, 3em6, 1rv7, 1t7j, 3ggu – HIVP (mutant) + drug
    
  • 4obd, 4obf, 4obg, 4obh, 4obj, 4obk – HIVP (mutant) + peptide
    
  • 1fej, 1ff0, 1fff, 1ffi, 1fg6, 1fg8, 1fgc – HIVP (mutant) + substrate analog
    
• HIV-I protease complex at the top of the flap
  • 4ej8, 4ejl – HIVP (mutant) + indole derivative
    
  • 4k4q – HIVP (mutant) + bromobenzoate derivative
    
  • 4k4r – HIVP (mutant) + bromonaphthoate derivative
    
  • 4ejd, 4ejk – HIVP + pepstatin peptide + indole derivative
    
  • 4tvh – HIVP + inhibitor + indole derivative
    
• Synthetic HIV-I protease
  • 2o40 – syHIVP - synthetic
    
  • 3hau, 3haw, 3nwq, 3nwx, 3nxe, 3nxn, 3nyg, 4hvp – syHIVP + inhibitor
    
  • 3hlo, 3ia9, 3fsm, 3gi0, 3iaw, 3ka2, 3i2l, 7hvp, 8hvp – syHIVP (mutant) + inhibitor
    
• HIV-II
  • 3ebz – HIVP + drug
    
  • 3ec0, 3ecg, 1ida, 1idb, 3ec0, 3ecg, 1ivq – HIVP + inhibitor
    
  • 3upj, 4upj, 1ivp, 6upj, 5upj – HIVP (mutant) + inhibitor
    
  • 5cay – HIVP + CD4
    
• FIV (Feline Immunodeficiency Virus)
  • 1b11, 5fiv, 6fiv, 4fiv, 2fiv, 3fiv, 1fiv, 3tlh – FIVP + inhibitor – cat immunodeficiency virus
    
  • 2hah – FIVP (mutant) + inhibitor
    
  • 3ogp, 3ogq – FIVP (mutant) + drug
    
• SIV (Simian Immunodeficiency Virus)
  • 1sip – SIVP – monkey immunodeficiency virus
    
  • 1az5 – SIVP (mutant)
    
  • 2siv, 1qbz – SIVP Gp41
    
  • 2bf1 – SIVP Gp120
    
  • 1tcw, 2sam, 1siv – SIVP + inhibitor
    
  • 1ytg, 1yth, 1yti, 1ytj – SIVP + peptide
    

Additional ResourcesAdditional Resources

For additional information, see:

• Human Immunodeficiency Virus
• Structural Biology of HIV, an interactive Flash graphic of the virion with explanations of its components.