Recombination-activating gene: Difference between revisions

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==Recombination Activating Gene Complex==
==Recombination Activating Gene Complex==
<StructureSection load='3jbw' size='340' side='right' caption='RAG1 (grey, pink) and RAG2 (green, yellow) complex with DNA and Zn+2 (grey) (PDB code [[3jbw]])'>
<StructureSection load='3jbw' size='340' side='right' caption='RAG1 (grey, pink) and RAG2 (green, yellow) complex with DNA and Zn+2 (grey) (PDB code [[3jbw]])'>
The '''RAG complex protein''' or '''V(D)J recombination-activating protein''' is composed of two subunits, RAG-1 and RAG-2. RAG-1 and RAG-2 are critical in T and B cell maturation, promoting an adaptive immune response.  
The '''RAG (Recombination Activating Gene) complex protein''' or '''V(D)J recombination-activating protein''' is composed of two subunits, RAG-1 and RAG-2. RAG-1 and RAG-2 are critical in T and B cell maturation, promoting an adaptive immune response.  


== Function ==
== Function ==

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Leah Umbarger, Michal Harel, Jaime Prilusky