6ff8: Difference between revisions

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'''Unreleased structure'''


The entry 6ff8 is ON HOLD
==Crystal structure of uncomplexed Rab32 in the active GTP-bound state at 2.13 Angstrom resolution==
 
<StructureSection load='6ff8' size='340' side='right' caption='[[6ff8]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6ff8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FF8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FF8 FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ff8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ff8 OCA], [http://pdbe.org/6ff8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ff8 RCSB], [http://www.ebi.ac.uk/pdbsum/6ff8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ff8 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/RAB32_HUMAN RAB32_HUMAN]] Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.<ref>PMID:12186851</ref> <ref>PMID:21255211</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Kecman, T]]
[[Category: Khan, A R]]
[[Category: Cell dynamic]]
[[Category: Gtp]]
[[Category: Rab]]
[[Category: Signaling protein]]
[[Category: Small gtpase]]
[[Category: Vesicle trafficking]]

Revision as of 11:21, 30 January 2019

Crystal structure of uncomplexed Rab32 in the active GTP-bound state at 2.13 Angstrom resolutionCrystal structure of uncomplexed Rab32 in the active GTP-bound state at 2.13 Angstrom resolution

Structural highlights

6ff8 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[RAB32_HUMAN] Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.[1] [2]

References

  1. ↑ Alto NM, Soderling J, Scott JD. Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics. J Cell Biol. 2002 Aug 19;158(4):659-68. Epub 2002 Aug 19. PMID:12186851 doi:http://dx.doi.org/10.1083/jcb.200204081
  2. ↑ Seto S, Tsujimura K, Koide Y. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. Traffic. 2011 Apr;12(4):407-20. doi: 10.1111/j.1600-0854.2011.01165.x. Epub 2011 , Feb 21. PMID:21255211 doi:10.1111/j.1600-0854.2011.01165.x

6ff8, resolution 2.13Å

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