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==Tryptophan Repressor TrpR from E.coli variant T44L T81M S88Y with Indole-3-acetic acid as ligand== | |||
<StructureSection load='6ekp' size='340' side='right' caption='[[6ekp]], [[Resolution|resolution]] 1.46Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ekp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EKP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EKP FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IAC:1H-INDOL-3-YLACETIC+ACID'>IAC</scene>, <scene name='pdbligand=P3G:3,6,9,12,15-PENTAOXAHEPTADECANE'>P3G</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6ejw|6ejw]], [[6ejz|6ejz]], [[6eni|6eni]], [[6enn|6enn]], [[6elb|6elb]], [[6elf|6elf]], [[6elg|6elg]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ekp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ekp OCA], [http://pdbe.org/6ekp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ekp RCSB], [http://www.ebi.ac.uk/pdbsum/6ekp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ekp ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/TRPR_ECOLI TRPR_ECOLI]] This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Herud-Sikimic, O]] | |||
[[Category: Hocker, B]] | [[Category: Hocker, B]] | ||
[[Category: Juergens, G]] | |||
[[Category: Shanmugaratnam, S]] | [[Category: Shanmugaratnam, S]] | ||
[[Category: | [[Category: Stiel, A C]] | ||
[[Category: | [[Category: Ligand binding]] | ||
[[Category: | [[Category: Transcription]] | ||
Revision as of 11:17, 30 January 2019
Tryptophan Repressor TrpR from E.coli variant T44L T81M S88Y with Indole-3-acetic acid as ligandTryptophan Repressor TrpR from E.coli variant T44L T81M S88Y with Indole-3-acetic acid as ligand
Structural highlights
Function[TRPR_ECOLI] This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region. |
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