Keratins: Difference between revisions
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Both microfilaments and microtubules are assembled from globular subunits of actin and tubulin respectively. In contrast, intermediate filaments (IFs) are composed of proteins that have a long fibrous structure that results from long stretches of alpha helical domains. | Both microfilaments and microtubules are assembled from globular subunits of actin and tubulin respectively. In contrast, intermediate filaments (IFs) are composed of proteins that have a long fibrous structure that results from long stretches of alpha helical domains. | ||
The basic building block of each intermediate filament is a dimer of a coiled-coil pair of IF proteins (see [[Coiled | The basic building block of each intermediate filament is a dimer of a coiled-coil pair of IF proteins (see [[Coiled coil]]). Each keratin filament is assembled as a hetero-dimer of a type I keratin coiled together with a type II keratin. <ref name="Hanukoglu-1983">PMID:6191871</ref>. Other types of IFs are mostly composed of homo-dimers <ref name="Godsel-2008" />. | ||
==Primary structures of keratins== | ==Primary structures of keratins== | ||