Histamine H1 receptor: Difference between revisions
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==Histamine H1 Receptor== | ==Histamine H1 Receptor== | ||
<StructureSection load='3RZE' size='340' side='right' caption='Histamine H1 receptor with an antagonist' scene=''> | <StructureSection load='3RZE' size='340' side='right' caption='Histamine H1 receptor with an antagonist doxepin (PDB code [[3rze]])' scene=''> | ||
Allergy symptoms are mostly caused by the release of histamine in response to allergens. The binding of histamine to the extracellular portion of the H1 receptor triggers a structural change of the transmembrane portion, leading to a change in the C terminal area. This c terminal region interacts with G proteins, leading to the activation of the Gq signalling pathway, which triggers allergy symptoms like itchy eyes and runny noses. Many allergy drugs are anti-histamines, in that they bind to the histamine receptor but do not cause the conformational change that leads to a response. | Allergy symptoms are mostly caused by the release of histamine in response to allergens. The binding of histamine to the extracellular portion of the '''H1 receptor''' triggers a structural change of the transmembrane portion, leading to a change in the C terminal area. This c terminal region interacts with G proteins, leading to the activation of the Gq signalling pathway, which triggers allergy symptoms like itchy eyes and runny noses. Many allergy drugs are anti-histamines, in that they bind to the histamine receptor but do not cause the conformational change that leads to a response. | ||