Sandbox Reserved 1502: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA, Severine Perrin

@@ Line 64: / Line 64: @@
-== Interaction with LEDGF/p75 ==
+== Interaction between the HIV integrase and LEDGF/p75 ==
-LEDGF/p75, or Lens epithelium-derived growth factor, is a cellular cofactor of HIV integrase. It promotes the viral integration of the retrovirus by tethering the preintegration complex to the chromatin. Research on the interaction between LEDGF/p75 and the integrase [https://www.nature.com/articles/nchembio.370] shows that it is possible to prevent this the contact between the two proteins. Thus, the viral DNA will not be inserted into the genome of the host cell.
+LEDGF/p75, or Lens epithelium-derived growth factor, is a cellular cofactor of HIV integrase. It promotes the viral integration of the retrovirus by tethering the preintegration complex to the chromatin. Research on the interaction between LEDGF/p75 and the integrase [https://www.nature.com/articles/nchembio.370] shows that it is possible to prevent contact between the two proteins. Thus, the viral DNA will not be inserted into the genome of the host cell.
-====Interaction with antiviral====
+====Use of antiviral to slow down infection ====
-An antiviral refers to a molecule disrupting the replication cycle of one or more viruses, thus allowing to slow down but rarely to stop a viral infection. Antiviral targeting specific regions of the integrase are used to prevent the replication of HIV. For exemple, the (6-chloro-2-oxo-4-phenyl-1,2-dihydroquinoline-3-yl)acetic acid, interacts with <scene name='80/802676/Site_of_interaction/7'>the binding site of the LEDGF/p75 cofactor</scene>. This site is situated in the core domain. Once it is fixed into the core domain, the LEDGF/p75 will not be able to join and viral integration of the retrovirus will not be possible anymore.
+An antiviral refers to a molecule disrupting the replication cycle of one or more viruses, thus allowing to slow down but rarely to stop a viral infection. Antiviral targeting specific regions of the integrase are used to prevent the replication of HIV. For example, the (6-chloro-2-oxo-4-phenyl-1,2-dihydroquinoline-3-yl)acetic acid, interacts with <scene name='80/802676/Site_of_interaction/7'>the binding site of the LEDGF/p75 cofactor</scene>. This site is situated in the core domain. Once it is fixed into the core domain, the LEDGF/p75 will not be able to join and viral integration of the retrovirus will not be possible anymore.
 The whole complex between the integrase and the cofactor is displayed on the Proteopedia page [[2b4j]].