Sandbox Reserved 1502: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA, Severine Perrin

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-====Structure and interaction with the antiviral====
-The new experimental antiviral, here the (6-chloro-2-oxo-4-phenyl-1,2-dihydroquinoline-3-yl)acetic acid, interacts with the site with which <scene name='80/802676/Site_of_interaction/7'>the cofactor bind with the LEDGF/p75 cofactor</scene>. This site is situated in the core domain.
-The molecule then inhibits the interaction between the LEDGF/p75 cofactor and the integrase.
-The whole complex between the integrase and the cofactor is displayed on the Proteopedia page [[2b4j]].
 == Interaction with LEDGF/p75 ==
-LEDGF/p75, or Lens epithelium-derived growth factor, is a cellular cofactor of HIV integrase. It promotes the viral integration of the retrovirus by tethering the preintegration complex to the chromatin. Research on the interaction between LEDGF/p75 and the integrase shows that it is possible to inhibit this interaction which prevents the viral DNA to be inserted into the genome of the host cell.
+LEDGF/p75, or Lens epithelium-derived growth factor, is a cellular cofactor of HIV integrase. It promotes the viral integration of the retrovirus by tethering the preintegration complex to the chromatin. Research on the interaction between LEDGF/p75 and the integrase [https://www.nature.com/articles/nchembio.370] shows that it is possible to prevent this the contact between the two proteins. Thus, the viral DNA will not be inserted into the genome of the host cell.
+====Interaction with antiviral====
+An antiviral refers to a molecule disrupting the replication cycle of one or more viruses, thus allowing to slow down but rarely to stop a viral infection. Antiviral targeting specific regions of the integrase are used to prevent the replication of HIV. For exemple, the (6-chloro-2-oxo-4-phenyl-1,2-dihydroquinoline-3-yl)acetic acid, interacts with <scene name='80/802676/Site_of_interaction/7'>the binding site of the LEDGF/p75 cofactor</scene>. This site is situated in the core domain. Once it is fixed into the core domain, the LEDGF/p75 will not be able to join and viral integration of the retrovirus will not be possible anymore.
+The whole complex between the integrase and the cofactor is displayed on the Proteopedia page [[2b4j]].
 == HIV ==