Sandbox Reserved 1502: Difference between revisions

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Revision as of 02:36, 11 January 2019 view source Severine Perrin (talk \| contribs) 109 edits No edit summary ← Older edit		Revision as of 02:38, 11 January 2019 view source Severine Perrin (talk \| contribs) 109 edits No edit summary Newer edit →
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	== Structure ==		== Structure ==

	HIV-1 integrase is composed of three domains: the N-terminal (residues 1-49), the core domain (residues 50-212) and the C-terminal domain (residues 213-288). The core domain is responsible for the catalytic activity of the enzyme. It contains three acidic residues, the D,D-35-E motif which plays a key role in catalysis. The N-terminal domain includes the conserved HHCC motif, which binds zinc. The C-terminal domain is less well conserved. [http://www.jbc.org/content/276/26/23213/F2.expansion.html]		HIV-1 integrase is composed of three domains: the N-terminal (residues 1-49), the core domain (residues 50-212) and the C-terminal domain (residues 213-288).[http://www.jbc.org/content/276/26/23213/F2.expansion.html]