Sandbox Reserved 1489: Difference between revisions
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== '''Function''' == | == '''Function''' == | ||
Mhp1 is a | Mhp1 is a trans-membrane protein bellowing to the nucleobase-cation-symport-1 (NCS1) transporter family from Microbacterium liquefaciens. | ||
A transporter effects the cellular uptake and release of a wide range of substances across biological membranes in all organisms. This is done by coupling the uphill movement of the substrate against its concentration gradient with the energetically favorable downhill gradient of a second substrate, often a proton or a cation. The kinetics and thermodynamics of the transporters can be explained by their alternating conformations.[doi: 10.1126/science.1186303] | |||
In the case of Mhp1, it allows the sodium dependent income of indolyl methyl- and benzyl-hydantoins (''Figure 1'') in the cell. Those are part of a salvage metabolic pathway leading to their conversion in amino acids. | |||
2JLN is one of the conformations of Mhp1. It is the outward-facing conformation without substrate. | 2JLN is one of the conformations of Mhp1. It is the outward-facing conformation without substrate. | ||
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[[Image:Structure of benzyl-hydantoin.jpg]] | [[Image:Structure of benzyl-hydantoin.jpg]] | ||
''Figure 1 : Structure of benzyl-hydantoin'' | ''Figure 1 : Structure of benzyl-hydantoin, the substrate of Mhp1'' | ||