Calpain: Difference between revisions
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CAP is a heterodimer containing a small 28kDa regulatory subunit which is identical for all CAPs and a large 80kDa catalytic subunit. CAP undergoes conformational change upon binding of Ca+2 ions resulting in closing of its active site cleft and activation as a cysteine protease. <ref>PMID:11893336</ref> | CAP is a heterodimer containing a small 28kDa regulatory subunit which is identical for all CAPs and a large 80kDa catalytic subunit. CAP undergoes conformational change upon binding of Ca+2 ions resulting in closing of its active site cleft and activation as a cysteine protease. <ref>PMID:11893336</ref> | ||
*<scene name='51/517369/Cv/ | *<scene name='51/517369/Cv/4'>1st Ca+2 coordination site</scene>. Water molecules are shown as red spheres. | ||
*<scene name='51/517369/Cv/ | *<scene name='51/517369/Cv/5'>2nd Ca+2 coordination site</scene>.<ref>PMID:16411745</ref> | ||
</StructureSection> | </StructureSection> | ||