6irc: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6irc is ON HOLD  until Paper Publication
+==C-terminal domain of Drosophila phospholipase b NORPA, methylated==
+<StructureSection load='6irc' size='340' side='right' caption='[[6irc]], [[Resolution|resolution]] 3.54&Aring;' scene=''>
-Authors: Ye, F., Li, J., Huang, Y., Liu, W., Zhang, M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6irc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IRC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IRC FirstGlance]. <br>
-Description: C-terminal domain of Drosophila phospholipase b NORPA, methylated
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoinositide_phospholipase_C Phosphoinositide phospholipase C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.11 3.1.4.11] </span></td></tr>
-[[Category: Zhang, M]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6irc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6irc OCA], [http://pdbe.org/6irc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6irc RCSB], [http://www.ebi.ac.uk/pdbsum/6irc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6irc ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/PIPA_DROME PIPA_DROME]] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway (PubMed:2457447). Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).[UniProtKB:Q9P212]<ref>PMID:2457447</ref> <ref>PMID:25639794</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Phosphoinositide phospholipase C]]
+[[Category: Huang, Y]]
+[[Category: Li, J]]
 [[Category: Liu, W]]
 [[Category: Ye, F]]
-[[Category: Li, J]]
+[[Category: Zhang, M]]
-[[Category: Huang, Y]]
+[[Category: Coiled coil]]
+[[Category: Drosophila]]
+[[Category: Hydrolase]]
+[[Category: Phospholipase beta]]