6nd8: Difference between revisions

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-'''Unreleased structure'''
-The entry 6nd8 is ON HOLD
+==RHODOCETIN IN COMPLEX WITH THE INTEGRIN ALPHA2-A DOMAIN AND BARIUM==
+<StructureSection load='6nd8' size='340' side='right' caption='[[6nd8]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-Authors: Stetefeld, J., McDougall, M.D., Loewen, P.C.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6nd8]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ND8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ND8 FirstGlance]. <br>
-Description: RHODOCETIN IN COMPLEX WITH THE INTEGRIN ALPHA2-A DOMAIN AND BARIUM
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nd8 OCA], [http://pdbe.org/6nd8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nd8 RCSB], [http://www.ebi.ac.uk/pdbsum/6nd8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nd8 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/SLEC_CALRH SLEC_CALRH]] Potent inhibitor of collagen-induced platelet aggregation. It acts by binding to the integrin alpha2A domain and blocks collagen binding to integrin alpha-2/beta-1 (ITGA2/ITGB1). The gamma/delta subunits mainly contribute to this activity.<ref>PMID:11121411</ref> <ref>PMID:12871211</ref>  [[http://www.uniprot.org/uniprot/ITA2_HUMAN ITA2_HUMAN]] Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. [[http://www.uniprot.org/uniprot/SLED_CALRH SLED_CALRH]] Potent inhibitor of collagen-induced platelet aggregation. It acts by binding to the integrin alpha2A domain and blocks collagen binding to integrin alpha-2/beta-1 (ITGA2/ITGB1). The gamma/delta subunits mainly contribute to this activity.<ref>PMID:11121411</ref> <ref>PMID:12871211</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Calloselasma rhodostoma]]
+[[Category: Loewen, P C]]
+[[Category: McDougall, M D]]
 [[Category: Stetefeld, J]]
-[[Category: Loewen, P.C]]
+[[Category: C-type lectin]]
-[[Category: Mcdougall, M.D]]
+[[Category: Cell adhesion]]
+[[Category: Cell adhesion-toxin complex]]
+[[Category: Coagulation]]
+[[Category: Integrin]]
+[[Category: Venom]]