3ihj: Difference between revisions

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==Human alanine aminotransferase 2 in complex with PLP==
==Human alanine aminotransferase 2 in complex with PLP==
<StructureSection load='3ihj' size='340' side='right' caption='[[3ihj]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='3ihj' size='340' side='right' caption='[[3ihj]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GPT2, AAT2, ALT2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GPT2, AAT2, ALT2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine_transaminase Alanine transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.2 2.6.1.2] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine_transaminase Alanine transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.2 2.6.1.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ihj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihj OCA], [http://pdbe.org/3ihj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ihj RCSB], [http://www.ebi.ac.uk/pdbsum/3ihj PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ihj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihj OCA], [http://pdbe.org/3ihj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ihj RCSB], [http://www.ebi.ac.uk/pdbsum/3ihj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ihj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ih/3ihj_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ih/3ihj_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>

Revision as of 12:50, 19 December 2018

Human alanine aminotransferase 2 in complex with PLPHuman alanine aminotransferase 2 in complex with PLP

Structural highlights

3ihj is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Gene:GPT2, AAT2, ALT2 (HUMAN)
Activity:Alanine transaminase, with EC number 2.6.1.2
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[ALAT2_HUMAN] Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Yang RZ, Blaileanu G, Hansen BC, Shuldiner AR, Gong DW. cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase. Genomics. 2002 Mar;79(3):445-50. PMID:11863375 doi:http://dx.doi.org/10.1006/geno.2002.6722

3ihj, resolution 2.30Å

Drag the structure with the mouse to rotate

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OCA
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