3bg1: Difference between revisions
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|GENE= SEC13, D3S1231E, SEC13L1, SEC13R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), NUP145, RAT10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]) | |GENE= SEC13, D3S1231E, SEC13L1, SEC13R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), NUP145, RAT10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]) | ||
|DOMAIN= | |||
|RELATEDENTRY=[[3bg0|3BG0]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bg1 OCA], [http://www.ebi.ac.uk/pdbsum/3bg1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bg1 RCSB]</span> | |||
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[[Category: wd repeat]] | [[Category: wd repeat]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:26:01 2008'' | ||
Revision as of 05:26, 31 March 2008
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| , resolution 3.00Å | |||||||
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| Gene: | SEC13, D3S1231E, SEC13L1, SEC13R (Homo sapiens), NUP145, RAT10 (Saccharomyces cerevisiae) | ||||||
| Related: | 3BG0
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Architecture of a Coat for the Nuclear Pore Membrane
OverviewOverview
The symmetric core of the nuclear pore complex can be considered schematically as a series of concentric cylinders. A peripheral cylinder coating the pore membrane contains the previously characterized, elongated heptamer that harbors Sec13-Nup145C in its middle section. Strikingly, Sec13-Nup145C crystallizes as a hetero-octamer in two space groups. Oligomerization of Sec13-Nup145C was confirmed biochemically. Importantly, the numerous interacting surfaces in the hetero-octamer are evolutionarily highly conserved, further underlining the physiological relevance of the oligomerization. The hetero-octamer forms a slightly curved, yet rigid rod of sufficient length to span the entire height of the proposed membrane-adjacent cylinder. In concordance with the dimensions and symmetry of the nuclear pore complex core, we suggest that the cylinder is constructed of four antiparallel rings, each ring being composed of eight heptamers arranged in a head-to-tail fashion. Our model proposes that the hetero-octamer would vertically traverse and connect the four stacked rings.
About this StructureAbout this Structure
3BG1 is a Protein complex structure of sequences from Homo sapiens and Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
ReferenceReference
Architecture of a coat for the nuclear pore membrane., Hsia KC, Stavropoulos P, Blobel G, Hoelz A, Cell. 2007 Dec 28;131(7):1313-26. PMID:18160040
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