6mg3: Difference between revisions

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-'''Unreleased structure'''
-The entry 6mg3 is ON HOLD  until Paper Publication
+==V285A Mutant of the C-terminal bZIP domain of human C/EBPbeta with 16bp Methylated Oligonucleotide Containing Consensus Recognition Sequence==
+<StructureSection load='6mg3' size='340' side='right' caption='[[6mg3]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
-Authors: Horton, J.R., Cheng, X., Yang, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6mg3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MG3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MG3 FirstGlance]. <br>
-Description: V285A Mutant of the C-terminal bZIP domain of human C/EBPbeta with 16bp Methylated Oligonucleotide Containing Consensus Recognition Sequence
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mg3 OCA], [http://pdbe.org/6mg3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mg3 RCSB], [http://www.ebi.ac.uk/pdbsum/6mg3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mg3 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CEBPB_HUMAN CEBPB_HUMAN]] Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation (By similarity). Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG).<ref>PMID:20829347</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Cheng, X]]
+[[Category: Horton, J R]]
 [[Category: Yang, J]]
-[[Category: Cheng, X]]
+[[Category: Bzip transciption factor dna methylation cpa methylation protein-dna complex]]
-[[Category: Horton, J.R]]
+[[Category: Transcription]]
+[[Category: Transcription-dna complex]]