6f5t: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6f5t is ON HOLD  until Paper Publication
+==Crystal Structure of KDM4D with tetrazole ligand GF057==
+<StructureSection load='6f5t' size='340' side='right' caption='[[6f5t]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
-Authors: Malecki, P.H., Link, A., Weiss, M.S., Heinemann, U.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6f5t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F5T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F5T FirstGlance]. <br>
-Description: Crystal Structure of KDM4D with tetrazole ligand GF057
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CQK:~{N}-oxidanyl-4-(2~{H}-1,2,3,4-tetrazol-5-yl)pyridine-2-carboxamide'>CQK</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f5t OCA], [http://pdbe.org/6f5t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f5t RCSB], [http://www.ebi.ac.uk/pdbsum/6f5t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f5t ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/KDM4D_HUMAN KDM4D_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Heinemann, U]]
-[[Category: Malecki, P.H]]
 [[Category: Link, A]]
-[[Category: Weiss, M.S]]
+[[Category: Malecki, P H]]
+[[Category: Weiss, M S]]
+[[Category: Cancer]]
+[[Category: Drug development]]
+[[Category: Epigenetic]]
+[[Category: Inhibitor design]]
+[[Category: Kdm4d]]
+[[Category: Ligand binding]]
+[[Category: Ligand optimization]]
+[[Category: Oxidoreductase]]
+[[Category: Tetrazole]]