Vacuolar protein sorting-associated protein: Difference between revisions
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*'''Vps33''' binds SNARE domains<ref>PMID:23051737</ref>.<br /> | *'''Vps33''' binds SNARE domains<ref>PMID:23051737</ref>.<br /> | ||
*'''Vps33A''' is part of the homotypic fusion and vacuole sorting comples which is required for fusion of intracellular compartments with lysosomes<ref>PMID:25783203</ref>.<br /> | *'''Vps33A''' is part of the homotypic fusion and vacuole sorting comples which is required for fusion of intracellular compartments with lysosomes<ref>PMID:25783203</ref>.<br /> | ||
*'''Vps36''' is part of the ESCRT-II complex<br /> | *'''Vps34''' is a class III [[Phosphoinositide 3-kinases]]<ref>PMID:21835792</ref>.<br /> | ||
*'''Vps36''' contains a ubiquitin-binding domain and is required for vacuolar sorting of ubiqinated membrane proteins. Vps36 is part of the ESCRT-II complex<ref>PMID:15755741</ref>.<br /> | |||
*'''Vps46''' is part of the ESCRT-II complex<ref>PMID:29046462</ref>.<br /> | |||
*'''Vps53''' C-terminal is important for binding endosome-derived vesicles<ref>PMID:20660722</ref>.<br /> | |||
*'''Vps54''' is part of the Golgi-associated retrograde protein complex (GARP) of vesicle sorting proteins<ref>PMID:18574757</ref>.<br /> | |||
== Disease == | |||
Mutations in Vps53 cause progressive cerebello-cerebral atrophy type 2<ref>PMID:24577744</ref>. Mutations in Vps54 in mice cause motor neuron disease<ref>PMID:16244655</ref>. | |||
== Relevance == | == Relevance == | ||
Vps25 in ''Drosophila'' possesses several properties of tumor repressor<ref>PMID:16256745</ref>. | Vps25 in ''Drosophila'' possesses several properties of tumor repressor<ref>PMID:16256745</ref>. Vps36 is downregulated in advanced prostate cancer<ref>PMID:28197629</ref>. | ||
== Structural highlights == | == Structural highlights == | ||