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|PDB= 3b2u |SIZE=350|CAPTION= <scene name='initialview01'>3b2u</scene>, resolution 2.580&Aring;
|PDB= 3b2u |SIZE=350|CAPTION= <scene name='initialview01'>3b2u</scene>, resolution 2.580&Aring;
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|SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Residue+A+3281'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Residue+A+3282'>AC2</scene>, <scene name='pdbsite=AC3:Bma+Binding+Site+For+Residue+A+3283'>AC3</scene>, <scene name='pdbsite=AC4:Man+Binding+Site+For+Residue+A+3284'>AC4</scene>, <scene name='pdbsite=AC5:Nag+Binding+Site+For+Residue+A+4201'>AC5</scene>, <scene name='pdbsite=AC6:Nag+Binding+Site+For+Residue+B+3281'>AC6</scene>, <scene name='pdbsite=AC7:Nag+Binding+Site+For+Residue+B+3282'>AC7</scene>, <scene name='pdbsite=AC8:Bma+Binding+Site+For+Residue+B+3283'>AC8</scene>, <scene name='pdbsite=AC9:Nag+Binding+Site+For+Residue+B+3371'>AC9</scene>, <scene name='pdbsite=BC1:Nag+Binding+Site+For+Residue+B+4201'>BC1</scene>, <scene name='pdbsite=BC2:Nag+Binding+Site+For+Residue+E+3281'>BC2</scene>, <scene name='pdbsite=BC3:Nag+Binding+Site+For+Residue+E+3282'>BC3</scene>, <scene name='pdbsite=BC4:Bma+Binding+Site+For+Residue+E+3283'>BC4</scene>, <scene name='pdbsite=BC5:Man+Binding+Site+For+Residue+E+3284'>BC5</scene>, <scene name='pdbsite=BC6:Nag+Binding+Site+For+Residue+E+3891'>BC6</scene>, <scene name='pdbsite=BC7:Nag+Binding+Site+For+Residue+E+4201'>BC7</scene>, <scene name='pdbsite=BC8:Nag+Binding+Site+For+Residue+I+3281'>BC8</scene>, <scene name='pdbsite=BC9:Nag+Binding+Site+For+Residue+I+3282'>BC9</scene>, <scene name='pdbsite=CC1:Bma+Binding+Site+For+Residue+I+3283'>CC1</scene>, <scene name='pdbsite=CC2:Man+Binding+Site+For+Residue+I+3284'>CC2</scene>, <scene name='pdbsite=CC3:Nag+Binding+Site+For+Residue+I+3891'>CC3</scene>, <scene name='pdbsite=CC4:Nag+Binding+Site+For+Residue+I+3892'>CC4</scene>, <scene name='pdbsite=CC5:Bma+Binding+Site+For+Residue+I+3893'>CC5</scene>, <scene name='pdbsite=CC6:Nag+Binding+Site+For+Residue+I+4201'>CC6</scene>, <scene name='pdbsite=CC7:Nag+Binding+Site+For+Residue+M+3281'>CC7</scene>, <scene name='pdbsite=CC8:Nag+Binding+Site+For+Residue+M+3282'>CC8</scene>, <scene name='pdbsite=CC9:Bma+Binding+Site+For+Residue+M+3283'>CC9</scene>, <scene name='pdbsite=DC1:Man+Binding+Site+For+Residue+M+3284'>DC1</scene>, <scene name='pdbsite=DC2:Nag+Binding+Site+For+Residue+M+3891'>DC2</scene>, <scene name='pdbsite=DC3:Nag+Binding+Site+For+Residue+M+3892'>DC3</scene>, <scene name='pdbsite=DC4:Bma+Binding+Site+For+Residue+M+3893'>DC4</scene>, <scene name='pdbsite=DC5:Nag+Binding+Site+For+Residue+M+4201'>DC5</scene>, <scene name='pdbsite=DC6:Nag+Binding+Site+For+Residue+M+4202'>DC6</scene>, <scene name='pdbsite=DC7:Nag+Binding+Site+For+Residue+P+3281'>DC7</scene>, <scene name='pdbsite=DC8:Nag+Binding+Site+For+Residue+P+3282'>DC8</scene>, <scene name='pdbsite=DC9:Bma+Binding+Site+For+Residue+P+3283'>DC9</scene>, <scene name='pdbsite=EC1:Nag+Binding+Site+For+Residue+P+3371'>EC1</scene>, <scene name='pdbsite=EC2:Nag+Binding+Site+For+Residue+P+3891'>EC2</scene>, <scene name='pdbsite=EC3:Nag+Binding+Site+For+Residue+P+4201'>EC3</scene>, <scene name='pdbsite=EC4:Nag+Binding+Site+For+Residue+S+3281'>EC4</scene>, <scene name='pdbsite=EC5:Nag+Binding+Site+For+Residue+S+3282'>EC5</scene>, <scene name='pdbsite=EC6:Bma+Binding+Site+For+Residue+S+3283'>EC6</scene>, <scene name='pdbsite=EC7:Nag+Binding+Site+For+Residue+S+4201'>EC7</scene>, <scene name='pdbsite=EC8:Nag+Binding+Site+For+Residue+V+3281'>EC8</scene>, <scene name='pdbsite=EC9:Nag+Binding+Site+For+Residue+V+3282'>EC9</scene>, <scene name='pdbsite=FC1:Bma+Binding+Site+For+Residue+V+3283'>FC1</scene>, <scene name='pdbsite=FC2:Nag+Binding+Site+For+Residue+V+3891'>FC2</scene>, <scene name='pdbsite=FC3:Nag+Binding+Site+For+Residue+V+4201'>FC3</scene>, <scene name='pdbsite=FC4:So4+Binding+Site+For+Residue+O+214'>FC4</scene>, <scene name='pdbsite=FC5:So4+Binding+Site+For+Residue+A+1'>FC5</scene>, <scene name='pdbsite=FC6:So4+Binding+Site+For+Residue+G+214'>FC6</scene>, <scene name='pdbsite=FC7:So4+Binding+Site+For+Residue+U+214'>FC7</scene>, <scene name='pdbsite=FC8:So4+Binding+Site+For+Residue+K+214'>FC8</scene>, <scene name='pdbsite=FC9:So4+Binding+Site+For+Residue+E+1'>FC9</scene>, <scene name='pdbsite=GC1:So4+Binding+Site+For+Residue+X+214'>GC1</scene> and <scene name='pdbsite=GC2:So4+Binding+Site+For+Residue+V+1'>GC2</scene>
|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> and <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1]  
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span>
|GENE= EGFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), EGFR, ERBB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= EGFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), EGFR, ERBB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|DOMAIN=
|RELATEDENTRY=[[3b2v|3B2V]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b2u OCA], [http://www.ebi.ac.uk/pdbsum/3b2u PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3b2u RCSB]</span>
}}
}}


'''Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8'''
'''Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8'''


==Disease==
Known disease associated with this structure: Adenocarcinoma of lung, response to tyrosine kinase inhibitor in OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]], Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]], Nonsmall cell lung cancer, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]]


==About this Structure==
==About this Structure==
Line 20: Line 26:
[[Category: Kussie, P.]]
[[Category: Kussie, P.]]
[[Category: Li, S.]]
[[Category: Li, S.]]
[[Category: NAG]]
[[Category: SO4]]
[[Category: alternative splicing]]
[[Category: alternative splicing]]
[[Category: anti-oncogene]]
[[Category: anti-oncogene]]
[[Category: antigen:antibody complex]]
[[Category: antitumor]]
[[Category: atp-binding]]
[[Category: atp-binding]]
[[Category: cell cycle]]
[[Category: cell cycle]]
[[Category: cell surface receptor; glycoprotein; antigen:antibody complex; fab fragment; antitumor; drug]]
[[Category: cell surface receptor]]
[[Category: disease mutation]]
[[Category: disease mutation]]
[[Category: drug]]
[[Category: fab fragment]]
[[Category: glycoprotein]]
[[Category: immune system/transferase complex]]
[[Category: immune system/transferase complex]]
[[Category: kinase]]
[[Category: kinase]]
Line 40: Line 49:
[[Category: ubl conjugation]]
[[Category: ubl conjugation]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:55:39 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:22:31 2008''

Revision as of 05:22, 31 March 2008

File:3b2u.jpg


PDB ID 3b2u

Drag the structure with the mouse to rotate
, resolution 2.580Å
Sites: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , and
Ligands: , , ,
Gene: EGFR (Homo sapiens), EGFR, ERBB1 (Homo sapiens)
Activity: Receptor protein-tyrosine kinase, with EC number 2.7.10.1
Related: 3B2V


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8


DiseaseDisease

Known disease associated with this structure: Adenocarcinoma of lung, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, susceptibility to OMIM:[131550]

About this StructureAbout this Structure

3B2U is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Page seeded by OCA on Mon Mar 31 05:22:31 2008

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