6cy9: Difference between revisions
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==SA11 Rotavirus NSP2 with disulfide bridge== | |||
<StructureSection load='6cy9' size='340' side='right' caption='[[6cy9]], [[Resolution|resolution]] 2.62Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6cy9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CY9 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6auk|6auk]], [[6cya|6cya]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cy9 OCA], [http://pdbe.org/6cy9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cy9 RCSB], [http://www.ebi.ac.uk/pdbsum/6cy9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cy9 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/A2T3N6_9REOV A2T3N6_9REOV]] Participates in replication and packaging of the viral genome. Plays a crucial role, together with NSP5, in the formation of virus factories (viroplasms) which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place. Displays ssRNA binding, NTPase, RNA triphosphatase (RTPase) and ATP-independent helix-unwinding activities. The unwinding activity may prepare and organize plus-strand RNAs for packaging and replication by removing interfering secondary structures. The RTPase activity plays a role in the removal of the gamma-phosphate from the rotavirus RNA minus strands of dsRNA genome segments.[HAMAP-Rule:MF_04089][RuleBase:RU364009] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Anish, R]] | |||
[[Category: Hu, L]] | |||
[[Category: Prasad, B V.V]] | |||
[[Category: Disulfide]] | |||
[[Category: Nsp2]] | |||
[[Category: Rotavirus sa11]] | |||
[[Category: Viral protein]] | |||
Revision as of 09:34, 5 December 2018
SA11 Rotavirus NSP2 with disulfide bridgeSA11 Rotavirus NSP2 with disulfide bridge
Structural highlights
Function[A2T3N6_9REOV] Participates in replication and packaging of the viral genome. Plays a crucial role, together with NSP5, in the formation of virus factories (viroplasms) which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place. Displays ssRNA binding, NTPase, RNA triphosphatase (RTPase) and ATP-independent helix-unwinding activities. The unwinding activity may prepare and organize plus-strand RNAs for packaging and replication by removing interfering secondary structures. The RTPase activity plays a role in the removal of the gamma-phosphate from the rotavirus RNA minus strands of dsRNA genome segments.[HAMAP-Rule:MF_04089][RuleBase:RU364009] |
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