Hormone sensitive lipase: Difference between revisions

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R. Jeremy Johnson, Michal Harel, Angel Herraez, Karsten Theis

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 __NOTOC__
-==Introduction==
 [[Image:HPL_firstimage.png|300 px|left|thumb|Hormone-Sensitive Lipase from [[3dnm]]. Alpha helices and beta sheets are shown in red and yellow, respectively.]]
-Hormone-sensitive [http://proteopedia.org/wiki/index.php/Lipase lipases] (HSL) represent a class of [http://en.wikipedia.org/wiki/Esterase esterases] within the [http://www.proteopedia.org/wiki/index.php/Hydrolase α/β hydrolase] family. HSL catalyzes the cleavage of ester bonds in fatty acid molecules when stimulated by a hormone.<ref name="Holm">PMID:14641008</ref> The activation and mobilization of hormone-sensitive lipase can be triggered by various [http://en.wikipedia.org/wiki/Catecholamine catecholamines] and inhibited by [http://www.proteopedia.org/wiki/index.php/Insulin insulin].<ref name= "Ray">PMID:12765952</ref> Catecholamines, such as [http://en.wikipedia.org/wiki/Epinephrine epinephrine], are rapidly spread throughout the body during times of energy mobilization, like in the [http://en.wikipedia.org/wiki/Fight-or-flight_response fight or flight response]. Conversely, insulin triggers glucose uptake, requiring the storage of energy, opposing HSL's function. HSL is clinically relevant, because the mobilization of or inability to mobilize fats in cells is directly related to fat accumulation seen in [http://en.wikipedia.org/wiki/Atherosclerosis artherosclerosis]and [http://en.wikipedia.org/wiki/Obesity obesity].<ref name= "Yeaman">PMID:14725507</ref>  Such diseases are characterized by an accumulation of fats and researchers are investigating whether HSL's activity plays a role or not.<ref name= "Ray">PMID:12765952</ref>  Investigation of HSL's structure and function could provide a better clinical understanding of these diseases.<ref name= "Yeaman">PMID:14725507</ref>
+'''Hormone-sensitive lipases''' (HSL) represent a class of [http://en.wikipedia.org/wiki/Esterase esterases] within the [http://www.proteopedia.org/wiki/index.php/Hydrolase α/β hydrolase] family. Like other [http://proteopedia.org/wiki/index.php/Lipase '''lipases'''], HSL catalyzes the cleavage of ester bonds in fatty acid molecules. The activation and mobilization of hormone-sensitive lipase can be triggered by various [http://en.wikipedia.org/wiki/Catecholamine catecholamines] and inhibited by [http://www.proteopedia.org/wiki/index.php/Insulin insulin].<ref name="Holm">PMID:14641008</ref><ref name= "Ray">PMID:12765952</ref> Catecholamines, such as [http://en.wikipedia.org/wiki/Epinephrine epinephrine], are rapidly spread throughout the body during times of energy mobilization, like in the [http://en.wikipedia.org/wiki/Fight-or-flight_response fight or flight response]. Conversely, insulin triggers glucose uptake, requiring the storage of energy, opposing HSL's function. HSL is clinically relevant, because the mobilization of or inability to mobilize fats in cells is directly related to fat accumulation seen in [http://en.wikipedia.org/wiki/Atherosclerosis artherosclerosis]and [http://en.wikipedia.org/wiki/Obesity obesity].<ref name= "Yeaman">PMID:14725507</ref>  Such diseases are characterized by an accumulation of fats and researchers are investigating whether HSL's activity plays a role or not.<ref name= "Ray">PMID:12765952</ref>  Investigation of HSL's structure and function could provide a better clinical understanding of these diseases.<ref name= "Yeaman">PMID:14725507</ref>
 ==Activation of HSL==