Sandbox Reserved 1456: Difference between revisions
No edit summary |
No edit summary |
||
| Line 22: | Line 22: | ||
The <scene name='79/799584/Catalytic_triad/1'>catalytic triad</scene> of Kgp is made up of Cys477-His444-Asp388. The ligand, CKC, is shown in red and the three amino acids of the catalytic triad are colored by elements (CPK). His444 and Asp388 use acid base catalysis with a covalent intermediate formed with Cys477 to cleave the peptide bond. The histidine imidazolium group transfers a proton to the leaving alpha-amine group of the cleavage product, leaving part of the substrate bound covalently as a thioester to the catalytic Cys477. | The <scene name='79/799584/Catalytic_triad/1'>catalytic triad</scene> of Kgp is made up of Cys477-His444-Asp388. The ligand, CKC, is shown in red and the three amino acids of the catalytic triad are colored by elements (CPK). His444 and Asp388 use acid base catalysis with a covalent intermediate formed with Cys477 to cleave the peptide bond. The histidine imidazolium group transfers a proton to the leaving alpha-amine group of the cleavage product, leaving part of the substrate bound covalently as a thioester to the catalytic Cys477. | ||
<scene name='79/799584/ | <scene name='79/799584/Active_site_2/1'>active site</scene> | ||
<scene name='79/799584/Catalytic_triad/1'>catalytic triad</scene> | <scene name='79/799584/Catalytic_triad/1'>catalytic triad</scene> | ||