3d46: Difference between revisions

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==Crystal structure of L-rhamnonate dehydratase from Salmonella typhimurium complexed with Mg and L-tartrate==
==Crystal structure of L-rhamnonate dehydratase from Salmonella typhimurium complexed with Mg and L-tartrate==
<StructureSection load='3d46' size='340' side='right' caption='[[3d46]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='3d46' size='340' side='right' caption='[[3d46]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3box|3box]], [[3d47|3d47]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3box|3box]], [[3d47|3d47]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">yfaW, STM2291 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">yfaW, STM2291 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d46 OCA], [http://pdbe.org/3d46 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3d46 RCSB], [http://www.ebi.ac.uk/pdbsum/3d46 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/3d46 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d46 OCA], [http://pdbe.org/3d46 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3d46 RCSB], [http://www.ebi.ac.uk/pdbsum/3d46 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3d46 ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/3d46 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d4/3d46_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d4/3d46_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>

Revision as of 11:40, 14 November 2018

Crystal structure of L-rhamnonate dehydratase from Salmonella typhimurium complexed with Mg and L-tartrateCrystal structure of L-rhamnonate dehydratase from Salmonella typhimurium complexed with Mg and L-tartrate

Structural highlights

3d46 is a 8 chain structure with sequence from Salty. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Gene:yfaW, STM2291 (SALTY)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

[RHMD_SALTY] Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR). Can also dehydrate L-lyxonate and L-mannonate, although less efficiently, but not 2-keto-4-hydroxyheptane-1,7-dioate.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. Rakus JF, Fedorov AA, Fedorov EV, Glasner ME, Hubbard BK, Delli JD, Babbitt PC, Almo SC, Gerlt JA. Evolution of enzymatic activities in the enolase superfamily: L-rhamnonate dehydratase. Biochemistry. 2008 Sep 23;47(38):9944-54. Epub 2008 Aug 29. PMID:18754693 doi:10.1021/bi800914r

3d46, resolution 1.90Å

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