2vis: Difference between revisions
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|PDB= 2vis |SIZE=350|CAPTION= <scene name='initialview01'>2vis</scene>, resolution 3.25Å | |PDB= 2vis |SIZE=350|CAPTION= <scene name='initialview01'>2vis</scene>, resolution 3.25Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | |LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vis OCA], [http://www.ebi.ac.uk/pdbsum/2vis PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2vis RCSB]</span> | |||
}} | }} | ||
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[[Category: Skehel, J J.]] | [[Category: Skehel, J J.]] | ||
[[Category: Wharton, S A.]] | [[Category: Wharton, S A.]] | ||
[[Category: complex (hemagglutinin/immmunoglobulin)]] | [[Category: complex (hemagglutinin/immmunoglobulin)]] | ||
[[Category: glycoprotein]] | [[Category: glycoprotein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:12:50 2008'' | ||
Revision as of 05:12, 31 March 2008
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| , resolution 3.25Å | |||||||
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| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
INFLUENZA VIRUS HEMAGGLUTININ, (ESCAPE) MUTANT WITH THR 131 REPLACED BY ILE, COMPLEXED WITH A NEUTRALIZING ANTIBODY
OverviewOverview
The structure of the hemagglutinin (HA) of a mutant influenza virus that escapes neutralization by a monoclonal antibody shows that the mutation causes changes in HA structure which avoid an energetically less favorable conformation. However, the structure of the mutant HA.Fab complex indicates that the antibody binds selectively to mutant HA in a wild type-like distorted conformation. The association of an antibody with a less favored HA conformation represents an alternative to previously described mechanisms of escape from neutralization by antibodies.
About this StructureAbout this Structure
2VIS is a Protein complex structure of sequences from Mus musculus and Unidentified influenza virus. Full crystallographic information is available from OCA.
ReferenceReference
Antigen distortion allows influenza virus to escape neutralization., Fleury D, Wharton SA, Skehel JJ, Knossow M, Bizebard T, Nat Struct Biol. 1998 Feb;5(2):119-23. PMID:9461077
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