Pseudouridine synthase: Difference between revisions
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better specify there are two types of complexes among the pseudouridine synthases |
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[[Pseudouridine]] is an abundant modified nucleotide found in RNA molecules. It is formed post-transcriptionally in RNA molecules by isomerization of the base of uridine. There are two major types of enzymes that catalyze this reaction: | [[Pseudouridine]] is an abundant modified nucleotide found in RNA molecules. It is formed post-transcriptionally in RNA molecules by isomerization of the base of uridine. There are two major types of enzymes that catalyze this reaction: | ||
* [[RNA-guided Pseudoridine synthase] -- | * [[RNA-guided Pseudoridine synthase]] -- Complexes of proteins and small RNAs have been identified in archaea and eukaryotes to catalyze these reactions. The small RNA in the complex serves as a guide element to specify the site of modification through base-pairing with the target RNA molecule. | ||
* [[Guide-independent Pseudouridine synthase]] -- The alternative to using the RNA-guided mechanism for pseudouridine formation is a [[Guide-independent Pseudouridine synthase|guide-independent mechanism]] acting through stand-alone enzymes to catalyze formation. | * [[Guide-independent Pseudouridine synthase]] -- The alternative to using the RNA-guided mechanism for pseudouridine formation is a [[Guide-independent Pseudouridine synthase|guide-independent mechanism]] acting through stand-alone enzymes to catalyze formation. | ||
Revision as of 20:07, 13 November 2018
FunctionPseudouridine is an abundant modified nucleotide found in RNA molecules. It is formed post-transcriptionally in RNA molecules by isomerization of the base of uridine. There are two major types of enzymes that catalyze this reaction:
Structural highlightsThe conversion of uridine to pseudouridine causes conformational change of PUS[1]. (1ze2). |
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